Gene Symbol | NSMCE4A |
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Entrez Gene | 54780 |
Alt Symbol | C10orf86, NS4EA, NSE4A |
Species | Human |
Gene Type | protein-coding |
Description | non-SMC element 4 homolog A (S. cerevisiae) |
Other Description | non-structural maintenance of chromosomes element 4 homolog A |
Swissprots | Q6P673 Q9BS90 Q5SQQ5 Q8WY66 Q9NXX6 |
Accessions | EAW49330 EAW49331 EAW49332 EAW49333 Q9NXX6 AF258584 AAG23787 AK000010 BAA90881 AK056579 AK222487 BAD96207 AK301658 BAG63134 AK308687 BC005212 AAH05212 BC062427 AAH62427 DA567626 XM_005269928 XP_005269985 XM_005269929 XP_005269986 XM_005269930 XP_005269987 XM_011539909 XP_011538211 XM_011539910 XP_011538212 XR_428706 NM_001167865 NP_001161337 NM_017615 NP_060085 |
Function | Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (APBs). Is involved in positive regulation of response to DNA damage stimulus. {ECO:0000269|PubMed:18086888}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:18086888}. Chromosome, telomere {ECO:0000305|PubMed:18086888}. |
NSE4A (N-20) - sc-248108 from Santa Cruz Biotechnology
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NSE4A (T-16) - sc-248110 from Santa Cruz Biotechnology
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Anti-NSMCE4A antibody - ab103209 from Abcam
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Anti-NSMCE4A antibody - C-terminal - ab178898 from Abcam
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Anti-NSMCE4A / NSE4A Antibody (aa36-65, AP) - LS-C238174 from LifeSpan Bioscience
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Anti-NSMCE4A / NSE4A Antibody (aa36-65, Biotin) - LS-C238176 from LifeSpan Bioscience
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Anti-NSMCE4A / NSE4A Antibody (aa36-65, APC) - LS-C238175 from LifeSpan Bioscience
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Anti-NSMCE4A / NSE4A Antibody (aa36-65, FITC) - LS-C238177 from LifeSpan Bioscience
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Anti-NSMCE4A / NSE4A Antibody (aa36-65, PE) - LS-C238178 from LifeSpan Bioscience
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Anti-NSMCE4A / NSE4A Antibody (aa36-65, Azide-free, HRP) - LS-C248953 from LifeSpan Bioscience
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Anti-NSMCE4A / NSE4A Antibody (aa36-65) - LS-C323456 from LifeSpan Bioscience
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Anti-NSMCE4A / NSE4A Antibody (aa240-289) - LS-C187123 from LifeSpan Bioscience
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Anti-NSMCE4A / NSE4A Antibody (aa29-57) - LS-C163020 from LifeSpan Bioscience
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Anti-NSMCE4A / NSE4A Antibody (C-Terminus) IHC-plus⢠- LS-B11563 from LifeSpan Bioscience
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NSMCE4A Antibody - NBP1-90789 from Novus Biologicals
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ANTI-NSE4A (N-TERM) antibody produced in rabbit - SAB1304575 from Sigma-Aldrich
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NSMCE4A Antibody - C-terminal region (ARP70963_P050) - ARP70963_P050 from Aviva Systems Biology
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NSMCE4A Antibody - C-terminal region (ARP70964_P050) - ARP70964_P050 from Aviva Systems Biology
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NSE4A-Antibody-N-term - AP9909a from Abgent, a WuXi AppTec company
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NSMCE4A Antibody - N-terminal region (OAAB06507) - OAAB06507 from Aviva Systems Biology
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NSMCE4A antibody - GTX121270 from GeneTex
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NSE4A antibody - orb40611 from Biorbyt
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NSE4A Antibody - abx034567 from Abbexa
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NSMCE4A (N-term) antibody - AP52941PU-N from Acris Antibodies
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NSMCE4A antibody - H00054780-B01P from Acris Antibodies
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