Gene Symbol | NSMCE4A |
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Entrez Gene | 54780 |
Alt Symbol | C10orf86, NS4EA, NSE4A |
Species | Human |
Gene Type | protein-coding |
Description | non-SMC element 4 homolog A (S. cerevisiae) |
Other Description | non-structural maintenance of chromosomes element 4 homolog A |
Swissprots | Q6P673 Q9BS90 Q5SQQ5 Q8WY66 Q9NXX6 |
Accessions | EAW49330 EAW49331 EAW49332 EAW49333 Q9NXX6 AF258584 AAG23787 AK000010 BAA90881 AK056579 AK222487 BAD96207 AK301658 BAG63134 AK308687 BC005212 AAH05212 BC062427 AAH62427 DA567626 XM_005269928 XP_005269985 XM_005269929 XP_005269986 XM_005269930 XP_005269987 XM_011539909 XP_011538211 XM_011539910 XP_011538212 XR_428706 NM_001167865 NP_001161337 NM_017615 NP_060085 |
Function | Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (APBs). Is involved in positive regulation of response to DNA damage stimulus. {ECO:0000269|PubMed:18086888}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:18086888}. Chromosome, telomere {ECO:0000305|PubMed:18086888}. |
NSMCE4A / NSE4A Antibody Blocking Peptide - LS-E25120 from LifeSpan Bioscience
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NSMCE4A / NSE4A Antibody Blocking Peptide - LS-E25121 from LifeSpan Bioscience
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NSMCE4A / NSE4A Antibody Blocking Peptide - LS-E10386 from LifeSpan Bioscience
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NSE4A-Antibody-N-term-Blocking-Peptide - BP9909a from Abgent, a WuXi AppTec company
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Recombinant Human Non-structural maintenance of chromosomes element 4 homolog A( - CSB-YP882137HU CSB-EP882137HU CSB-BP882137HU CSB-MP882137HU from Cusabio
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NSMCE4A - TP309357 from Acris Antibodies
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NSMCE4A Protein - NBP1-90789PEP from Novus Biologicals
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NSMCE4A Peptide, Human - M34GP10650H from Creative Peptides
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NSMCE4A Recombinant Protein Antigen - NBP2-55592PEP from Novus Biologicals
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NSMCE4A Recombinant Protein Antigen - NBP2-55189PEP from Novus Biologicals
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Non-structural maintenance of chromosomes element 4 homolog A (NSMCE4A), Recombinant Protein - MBS1350189 from MyBioSource
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