PPP1R8

Gene Symbol PPP1R8
Entrez Gene 5511
Alt Symbol ARD-1, ARD1, NIPP-1, NIPP1, PRO2047
Species Human
Gene Type protein-coding
Description protein phosphatase 1, regulatory subunit 8
Other Description RNase E|activator of RNA decay|nuclear inhibitor of protein phosphatase 1|nuclear inhibitor of protein phosphatase-1 alpha|nuclear subunit of PP-1|protein phosphatase 1 regulatory subunit 8|protein phosphatase 1, regulatory (inhibitor) subunit 8
Swissprots Q12972 Q5TIF2 Q5TEJ4 Q9UBH1 Q6PKF6 Q5TEJ2 Q9UBZ0
Accessions AAD24669 AAD24670 EAX07731 EAX07732 EAX07733 EAX07734 EAX07735 EAX07736 Q12972 AF061958 AAD31541 AF061959 AAD31542 AF126488 AAD22486 AK292077 BAF84766 AK297771 BAG60117 AK304619 BAG65401 AK307570 AK313814 BAG36550 AX775985 CAE11692 BC001597 AAH01597 BC003405 BC013360 AAH13360 BC093017 AAH93017 BI459680 CR450309 CAG29305 DA077576 DA167043 DA693246 DQ223931 ABB04281 HQ448661 ADQ33139 U14575 AAA64749 NM_002713 NP_002704 NM_014110 NP_054829 NM_138558 NP_612568
Function Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.
Subcellular Location Nucleus. Nucleus speckle. Note=Primarily, but not exclusively, nuclear.
Tissue Specificity Ubiquitously expressed, with highest levels in heart and skeletal muscle, followed by brain, placenta, lung, liver and pancreas. Less abundant in kidney. The concentration and ratio between isoforms is cell-type dependent. Isoform Alpha (>90%) and isoform Beta were found in brain, heart and kidney. Isoform Gamma is mainly found in B-cells and T-lymphocytes, and has been found in 293 embryonic kidney cells. {ECO:0000269|PubMed:10103062, ECO:0000269|PubMed:7499293}.

NIPP1 (A-11) - sc-393991 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NIPP1 (A-11): sc-393991. Western blot analysis of NIPP1 expression in Jurkat (A), KNRK (B), SJRH30 (C), Saos-2 (D) and SK-N-MC (E) whole cell lysates.

NIPP1 (B-4) - sc-271749 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NIPP1 (B-4): sc-271749. Western blot analysis of NIPP1 expression in SJRH30 (A), Saos-2 (B), SK-N-MC (C) and KNRK (D) whole cell lysates.

NIPP1 (P-19) - sc-67704 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NIPP1 (P-19): sc-67704. Western blot analysis of NIPP1 expression in non-transfected: sc-117752 (A) and mouse NIPP1 transfected: sc-125708 (B) 293T whole cell lysates.

NIPP1 (V-20) - sc-67705 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

NIPP1 (C-18) - sc-67702 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

NIPP1 (G-19) - sc-67703 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NIPP1 (G-19): sc-67703. Western blot analysis of NIPP1 expression in non-transfected: sc-117752 (A) and mouse NIPP1 transfected: sc-125708 (B) 293T whole cell lysates.

NIPP1 (4) - sc-136425 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NIPP1 (4): sc-136425. Western blot analysis of NIPP1 expression in Jurkat whole cell lysate.

Anti-NIPP1 antibody - ab88143 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Anti-NIPP1 antibody (ab88143) at 1 µg/ml + immunogen (recombinant full length protein with a proprietary tag of 26kDa) at 0.2 µg/mlSecondaryGoat anti-Mouse IgG at 1/5000 dilution

Anti-NIPP1 antibody - ab137929 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-NIPP1 antibody (ab137929) at 1/500 dilution + HUVEC cell lysate at 30 µg

Anti-NIPP1 antibody [EPR14579(B)] - ab181852 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14579(B)
All lanes : Anti-NIPP1 antibody [EPR14579(B)] (ab181852) at 1/20000 dilutionLane 1 : HeLa cell lysateLane 2 : HepG2 cell lysateLane 3 : Jurkat cell lysateLane 4 : 293T cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L) HRP at 1/1000 dilution

Anti-PPP1R8 / Rnase E Antibody (aa237-282) - LS-C313857 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PPP1R8 / Rnase E Antibody (aa91-140) - LS-C30840 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
A: Marker, B: HepG2 Cell Lysate

Anti-PPP1R8 / Rnase E Antibody (aa215-264) - LS-C101840 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PPP1R8 antibody LS-C101840 Western blot of 293T cell lysate.

Anti-PPP1R8 / Rnase E Antibody (aa35-84) - LS-C116182 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PPP1R8 antibody LS-C116182 Western blot of OVCAR-3 cell lysate.

Anti-PPP1R8 / Rnase E Antibody (aa71-120) - LS-C31512 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
PPP1R8 antibody LS-C31512 was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.

Anti-PPP1R8 / Rnase E Antibody (aa178-227) - LS-C200514 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from HUVEC cells using PPP1R8 antibody.

Anti-PPP1R8 / Rnase E Antibody (aa1-225, clone 2B2) - LS-C339334 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2B2
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PPP1R8 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PPP1R8.

Anti-PPP1R8 / Rnase E Antibody (aa196-245) - LS-C120168 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from Jurkat cells, using PPP1R8 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-PPP1R8 / Rnase E Antibody (aa1-225, clone 2E12) - LS-C339333 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2E12
IHC of paraffin-embedded Human Kidney tissue using anti-PPP1R8 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-PPP1R8 / Rnase E Antibody (aa1-225, clone 1E9) - LS-C340641 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1E9
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PPP1R8 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PPP1R8.

Anti-PPP1R8 / Rnase E Antibody - LS-C335631 from LifeSpan Bioscience

Prices $315.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using PPP1R8 antibody.

Anti-PPP1R8 / Rnase E Antibody - LS-C334888 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using PPP1R8 antibody.

Anti-PPP1R8 / Rnase E Antibody (aa1-225, clone 5H9) - LS-C339337 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5H9
IHC of paraffin-embedded Carcinoma of Human kidney tissue using anti-PPP1R8 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-PPP1R8 / Rnase E Antibody (aa1-225, clone 4D5) - LS-C339335 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4D5
IHC of paraffin-embedded Carcinoma of Human pancreas tissue using anti-PPP1R8 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-PPP1R8 / Rnase E Antibody (aa1-225, clone 1E2) - LS-C340639 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1E2
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PPP1R8 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PPP1R8.
Search more