PPP1R8

Gene Symbol	PPP1R8
Entrez Gene	5511
Alt Symbol	ARD-1, ARD1, NIPP-1, NIPP1, PRO2047
Species	Human
Gene Type	protein-coding
Description	protein phosphatase 1, regulatory subunit 8
Other Description	RNase E|activator of RNA decay|nuclear inhibitor of protein phosphatase 1|nuclear inhibitor of protein phosphatase-1 alpha|nuclear subunit of PP-1|protein phosphatase 1 regulatory subunit 8|protein phosphatase 1, regulatory (inhibitor) subunit 8
Swissprots	Q12972 Q5TIF2 Q5TEJ4 Q9UBH1 Q6PKF6 Q5TEJ2 Q9UBZ0
Accessions	AAD24669 AAD24670 EAX07731 EAX07732 EAX07733 EAX07734 EAX07735 EAX07736 Q12972 AF061958 AAD31541 AF061959 AAD31542 AF126488 AAD22486 AK292077 BAF84766 AK297771 BAG60117 AK304619 BAG65401 AK307570 AK313814 BAG36550 AX775985 CAE11692 BC001597 AAH01597 BC003405 BC013360 AAH13360 BC093017 AAH93017 BI459680 CR450309 CAG29305 DA077576 DA167043 DA693246 DQ223931 ABB04281 HQ448661 ADQ33139 U14575 AAA64749 NM_002713 NP_002704 NM_014110 NP_054829 NM_138558 NP_612568
Function	Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.
Subcellular Location	Nucleus. Nucleus speckle. Note=Primarily, but not exclusively, nuclear.
Tissue Specificity	Ubiquitously expressed, with highest levels in heart and skeletal muscle, followed by brain, placenta, lung, liver and pancreas. Less abundant in kidney. The concentration and ratio between isoforms is cell-type dependent. Isoform Alpha (>90%) and isoform Beta were found in brain, heart and kidney. Isoform Gamma is mainly found in B-cells and T-lymphocytes, and has been found in 293 embryonic kidney cells. {ECO:0000269|PubMed:10103062, ECO:0000269|PubMed:7499293}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NIPP1 full length protein - ab131705 from Abcam Category Protein Source E. coli Species Human

Human NIPP1 peptide - ab23096 from Abcam Category Peptide Species Human

Human NIPP1 protein fragment - ab114902 from Abcam Category Protein Source Wheat germ Species Human

PPP1R8 / Rnase E Antibody Blocking Peptide - LS-E14731 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PPP1R8 / Rnase E Antibody Blocking Peptide - LS-E14732 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PPP1R8 / Rnase E Antibody Blocking Peptide - LS-E14932 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PPP1R8 / Rnase E Antibody Blocking Peptide - LS-E14933 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PPP1R8 / Rnase E Antibody Blocking Peptide - LS-E25577 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NIPP1 Recombinant Protein - H00005511-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

NIPP1 Partial Recombinant Protein - H00005511-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human NIPP1 Protein - NBP2-23382 from Novus Biologicals Category Protein Prices $269.00 Sizes 50 µg Source E.coli Species Human

Human PPP1R8 protein - orb169070 from Biorbyt Category Protein Prices $230.00, $442.00 Sizes 2 μg, 10 μg Source E.coli Species Human

PPP1R8 Blocking Peptide - 33R-9473 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PPP1R8 Blocking Peptide - 33R-7235 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PPP1R8 Blocking Peptide - 33R-2025 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PPP1R8 Blocking Peptide - 33R-9105 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PPP1R8 protein (His tag) - 80R-2447 from Fitzgerald Category Protein Prices $270.00 Sizes 50 µg Source E.coli

NIPP1 Peptide - AC21-0406-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

NIPP-1 (1-351, His-tag) - AR50527PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 250 µg Source E. coli Species Human

NIPP-1 (1-351, His-tag) - AR50527PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 50 µg Source E. coli Species Human

NIPP-1 - H00005511-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

NIPP-1 - H00005511-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

NIPP-1 - H00005511-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PPP1R8, 1-351aa, Human, His tag, E.coli - 01-P1703 from ARP American Research Products Category Protein Prices $149.00, $369.00, $849.00 Sizes 10 µg, 50 µg, 250 µg Species Human

NIPP1 Peptide - 45-968P from ProSci Category Peptide Species Human

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