| Gene Symbol |
PPP1R8
|
| Entrez Gene |
5511
|
| Alt Symbol |
ARD-1, ARD1, NIPP-1, NIPP1, PRO2047
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein phosphatase 1, regulatory subunit 8
|
| Other Description |
RNase E|activator of RNA decay|nuclear inhibitor of protein phosphatase 1|nuclear inhibitor of protein phosphatase-1 alpha|nuclear subunit of PP-1|protein phosphatase 1 regulatory subunit 8|protein phosphatase 1, regulatory (inhibitor) subunit 8
|
| Swissprots |
Q12972 Q5TIF2 Q5TEJ4 Q9UBH1 Q6PKF6 Q5TEJ2 Q9UBZ0
|
| Accessions |
AAD24669 AAD24670 EAX07731 EAX07732 EAX07733 EAX07734 EAX07735 EAX07736 Q12972 AF061958 AAD31541 AF061959 AAD31542 AF126488 AAD22486 AK292077 BAF84766 AK297771 BAG60117 AK304619 BAG65401 AK307570 AK313814 BAG36550 AX775985 CAE11692 BC001597 AAH01597 BC003405 BC013360 AAH13360 BC093017 AAH93017 BI459680 CR450309 CAG29305 DA077576 DA167043 DA693246 DQ223931 ABB04281 HQ448661 ADQ33139 U14575 AAA64749 NM_002713 NP_002704 NM_014110 NP_054829 NM_138558 NP_612568
|
| Function |
Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.
|
| Subcellular Location |
Nucleus. Nucleus speckle. Note=Primarily, but not exclusively, nuclear.
|
| Tissue Specificity |
Ubiquitously expressed, with highest levels in heart and skeletal muscle, followed by brain, placenta, lung, liver and pancreas. Less abundant in kidney. The concentration and ratio between isoforms is cell-type dependent. Isoform Alpha (>90%) and isoform Beta were found in brain, heart and kidney. Isoform Gamma is mainly found in B-cells and T-lymphocytes, and has been found in 293 embryonic kidney cells. {ECO:0000269|PubMed:10103062, ECO:0000269|PubMed:7499293}.
|