| Gene Symbol |
PLIN5
|
| Entrez Gene |
440503
|
| Alt Symbol |
LSDA5, LSDP5, MLDP, OXPAT
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
perilipin 5
|
| Other Description |
lipid storage droplet protein 5|perilipin-5
|
| Swissprots |
Q6ZS68 A2RRC1 Q00G26
|
| Accessions |
Q00G26 AW445065 BC033570 BC131524 AAI31525 BX105717 DQ839131 ABH07519 NM_001013706 NP_001013728
|
| Function |
Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Lipid droplet {ECO:0000269|PubMed:17234449}. Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}. Note=Lipid droplet surface-associated. Exchanges between lipid droplets and the cytoplasm (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Expressed in skeletal muscle, liver, heart and kidney. {ECO:0000269|PubMed:17234449}.
|