Gene Symbol | HIST1H4G |
---|---|
Entrez Gene | 8369 |
Alt Symbol | H4/l, H4FL |
Species | Human |
Gene Type | protein-coding |
Description | histone cluster 1, H4g |
Other Description | H4 histone family, member L|histone 1, H4g|histone H4-like protein type G |
Swissprots | Q99525 |
Accessions | AAN01445 CAB02550 EAW55550 Q99525 BC126276 AAI26277 BC126278 AAI26279 HQ258035 ADR82789 NM_003547 NP_003538 |
Function | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. |
Top Pathways | Systemic lupus erythematosus, Viral carcinogenesis, Alcoholism |