| Gene Symbol |
KIF14
|
| Entrez Gene |
9928
|
| Alt Symbol |
MKS12
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
kinesin family member 14
|
| Other Description |
kinesin-like protein KIF14
|
| Swissprots |
Q15058 Q14CI8 Q5T1W3 Q4G0A5
|
| Accessions |
CAI40582 CBX51368 EAW91315 EAW91316 EAW91317 Q15058 BC098582 AAH98582 BC113742 AAI13743 BC144068 BE644769 BQ425495 CN307042 CR748178 D26361 BAA05392 HQ258545 ADR83299 XM_011510230 XP_011508532 XM_011510231 XP_011508533 XM_011510232 XP_011508534 XM_011510233 XP_011508535 XM_011510234 XP_011508536 XM_011510235 XP_011508537 XM_011510236 XP_011508538 NM_001305792 NP_001292721 NM_014875 NP_055690
|
| Function |
Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:24784001, PubMed:16648480). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congres
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:16431929}. Cytoplasm {ECO:0000269|PubMed:16648480}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:16431929}. Midbody {ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:20309963}. Note=Nuclear localization observed during interphase (PubMed:16431929). Nuclear localization triggered by entry into mitosis (PubMed:16648480). Cytoplasmic in interphase (PubMed:16648480). Cytoplasmic in metaphase cells (PubMed:16431929). From prophase to metaphase, accumulates at the developing spindle poles and their associated microtubules. During anaphase, accumulates at the spindle midzone. Localization to the central spindle and midbody during anaphase is dependent upon PRC1 and CIT presence. In cells ready to undergo abscission, concentrates at the contractile ring. {ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:16648480}.
|
