KIF14

Gene Symbol KIF14
Entrez Gene 9928
Alt Symbol MKS12
Species Human
Gene Type protein-coding
Description kinesin family member 14
Other Description kinesin-like protein KIF14
Swissprots Q15058 Q14CI8 Q5T1W3 Q4G0A5
Accessions CAI40582 CBX51368 EAW91315 EAW91316 EAW91317 Q15058 BC098582 AAH98582 BC113742 AAI13743 BC144068 BE644769 BQ425495 CN307042 CR748178 D26361 BAA05392 HQ258545 ADR83299 XM_011510230 XP_011508532 XM_011510231 XP_011508533 XM_011510232 XP_011508534 XM_011510233 XP_011508535 XM_011510234 XP_011508536 XM_011510235 XP_011508537 XM_011510236 XP_011508538 NM_001305792 NP_001292721 NM_014875 NP_055690
Function Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:24784001, PubMed:16648480). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congres
Subcellular Location Nucleus {ECO:0000269|PubMed:16431929}. Cytoplasm {ECO:0000269|PubMed:16648480}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:16431929}. Midbody {ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:20309963}. Note=Nuclear localization observed during interphase (PubMed:16431929). Nuclear localization triggered by entry into mitosis (PubMed:16648480). Cytoplasmic in interphase (PubMed:16648480). Cytoplasmic in metaphase cells (PubMed:16431929). From prophase to metaphase, accumulates at the developing spindle poles and their associated microtubules. During anaphase, accumulates at the spindle midzone. Localization to the central spindle and midbody during anaphase is dependent upon PRC1 and CIT presence. In cells ready to undergo abscission, concentrates at the contractile ring. {ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:16648480}.

KIF14 CRISPR/Cas9 KO Plasmid (h) - sc-408805 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIF14 HDR Plasmid (h) - sc-408805-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIF14 Double Nickase Plasmid (h) - sc-408805-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIF14 Double Nickase Plasmid (h2) - sc-408805-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIF14 CRISPR Activation Plasmid (h) - sc-408805-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIF14 CRISPR Activation Plasmid (h2) - sc-408805-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIF14 Lentiviral Activation Particles (h) - sc-408805-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIF14 Lentiviral Activation Particles (h2) - sc-408805-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIF14 siRNA (h) - sc-60882 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KIF14 shRNA Plasmid (h) - sc-60882-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KIF14 shRNA (h) Lentiviral Particles - sc-60882-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU137791 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN11175 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11175 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

KIF14 siRNA (Human) - CRH6673 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human KIF14 (NM_014875.2) - SHH324999 from Creative biogene

Category siRNA
Species Reactivities Human

Human KIF14 siRNA - orb267175 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

KIF14 shRNA Plasmid (Human) - CHH6673 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

KIF14 miRNA 3'UTR clone - MiUTR3H-11768 from Creative biogene

Species Reactivities Human
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