PRKAR1A

Gene Symbol PRKAR1A
Entrez Gene 5573
Alt Symbol ACRDYS1, ADOHR, CAR, CNC, CNC1, PKR1, PPNAD1, PRKAR1, TSE1
Species Human
Gene Type protein-coding
Description protein kinase, cAMP-dependent, regulatory, type I, alpha
Other Description Carney complex type 1|cAMP-dependent protein kinase regulatory subunit RIalpha|cAMP-dependent protein kinase type I-alpha regulatory chain|cAMP-dependent protein kinase type I-alpha regulatory subunit|protein kinase A type 1a regulatory subunit|tissue-specific extinguisher 1
Swissprots K7ER48 Q567S7 P10644
Accessions AAL05860 ABC96005 ABC96006 ABC96007 EAW89060 EAW89061 EAW89062 EAW89063 EAW89064 EAW89065 P10644 A12295 CAA01027 AA015682 AI074326 AK097580 BAG53489 AK124586 AK312307 BAG35232 AL050038 AL535889 AW732104 AY007115 BC036285 AAH36285 BC093042 AAH93042 BM928493 BU167718 BU188258 CR749311 CAH18166 DA108801 DA219203 DA413808 DQ891775 ABM82701 DQ894959 ABM85885 M18468 AAB50922 M33336 AAB50921 S54705 S54707 S54709 S54711 Y07642 CAA68925 XM_011524983 XP_011523285 XM_011524984 XP_011523286 XM_011524985 XP_011523287 NM_001276289 NP_001263218 NM_001276290 NP_001263219 NM_001278433 NP_001265362 NM_002734 NP_002725 NM_212471 NP_997636 NM_212472 NP_997637
Function Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. {ECO:0000269|PubMed:16491121, ECO:0000269|PubMed:20215566}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:23115245}.
Tissue Specificity Four types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
Top Pathways Apoptosis, Insulin signaling pathway

PKA RI-α (D54D9) Rabbit mAb - 5675 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D54D9
Western blot analysis of extracts from MEF wild-type, MEF PKA RI-α (-/-) and HeLa cells using PKA RI-α (D54D9) Rabbit mAb. MEF wild-type and PKA RI-α (-/-) cells were kindly provided by Dr. Lawrence Kirschner, The Ohio State University, Columbus, OH.

PKA Iα reg (C-14) - sc-18800 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PKA Iα reg (C-14): sc-18800. Western blot analysis of PKA Iα reg expression in SW-13 whole cell lysate.

PKA Iα reg (N-15) - sc-18798 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PKA Iα reg (N-15): sc-18798. Immunoperoxidase staining of formalin fixed, paraffin-embedded human testis tissue showing cytoplasmic and membrane staining of cells in seminiferous ducts and cytoplasmic staining of Leydig cells.

PKA Iα reg (20) - sc-136231 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
PKA Iα reg (20): sc-136231. Western blot analysis of PKA Iα reg expression in rat cerebrum tissue extract.

PKA Iα/β reg (B-6) - sc-271125 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PKA Iα/β reg (B-6): sc-271125. Immunoperoxidase staining of formalin fixed, paraffin-embedded human bone marrow tissue showing cytoplasmic staining of hematopoietic cells.

PKA Iα/β reg (G-6) - sc-271446 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PKA I&alpha/β reg (G-6): sc-271446. Western blot analysis of PKA Iβ reg expression in non-transfected: sc-117752 (A) and human PKA Iβ reg transfected: sc-112159 (B) 293T whole cell lysates.

PKA Iα/β reg (H-90) - sc-28893 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PKA Iα/β reg (H-90): sc-28893. Western blot analysis of PKA Iα reg expression in non-transfected: sc-117752 (A) and mouse PKA Iα reg transfected: sc-110206 (B) 293T whole cell lysates.

Anti-Protein Kinase A regulatory subunit I alpha (phospho S77) antibody [EPMAYR1] - ab139682 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPMAYR1
All lanes : Anti-Protein Kinase A regulatory subunit I alpha (phospho S77) antibody [EPMAYR1] (ab139682) at 1/1000 dilutionLane 1 : Fetal heart lysateLane 2 : Fetal heart lysate treated with Alkaline Phosphatase.Lysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-Protein Kinase A regulatory subunit I alpha (phospho S83) antibody [EPMAYR1] - ab154851 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPMAYR1
All lanes : Anti-Protein Kinase A regulatory subunit I alpha (phospho S83) antibody [EPMAYR1] (ab154851) at 1/1000 dilutionLane 1 : Rat heart lysate; untreatedLane 2 : Rat heart lysate; treated with alkaline phosphataseLysates/proteins at 10 µg per lane.

Anti-Protein Kinase A regulatory subunit I alpha antibody - ab38936 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Protein Kinase A regulatory subunit I alpha antibody - ab65013 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Protein Kinase A regulatory subunit I alpha antibody (ab65013) at 1/500 dilutionLane 1 : HepG2 cell extract Lane 2 : HepG2 cell extract with immunizing peptide at 5 µgLysates/proteins at 10 µg per lane.

Anti-Protein Kinase A regulatory subunit I alpha antibody [3546C2a] - ab60064 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3546C2a

Anti-Protein Kinase A regulatory subunit I alpha antibody [6C7] - ab118061 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 6C7
All lanes : Anti-Protein Kinase A regulatory subunit I alpha antibody [6C7] (ab118061) at 1/2000 dilutionLane 1 : HEK293T cell lysate, transfected with the pCMV6-ENTRY control cDNA Lane 2 : HEK293T cell lysate, transfected with pCMV6-ENTRY Protein Kinase A regulatory subunit I alpha cDNA Lysates/proteins at 5 µg per lane.

Anti-Protein Kinase A regulatory subunit I alpha antibody [EPR8491] - ab139695 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8491
All lanes : Anti-Protein Kinase A regulatory subunit I alpha antibody [EPR8491] (ab139695) at 1/1000 dilutionLane 1 : Human fetal heart lysateLane 2 : 293T cell lysateLane 3 : U-87 MG cell lysateLysates/proteins at 10 µg per lane.SecondaryStandard HRP labelled goat anti-rabbit at 1/2000 dilutiondeveloped using the ECL technique

Anti-Protein Kinase A regulatory subunit I alpha antibody - N-terminal - ab180825 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human esophagus tissue labelling Protein Kinase A regulatory subunit I alpha with ab180825 at 1/100. Magnification: 200x.

Anti-Protein Kinase A regulatory subunit I alpha antibody - N-terminal - ab195444 from Abcam

Prices $370.00
Sizes 200 µg
Host Chicken
Clonality Polyclonal

Anti-PRKAR1A Antibody - LS-C75190 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-PRKAR1A / PKR1 Antibody - LS-C131711 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-PRKAR1A Antibody (clone 11C1062) - LS-C184098 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone 11C1062

Anti-PRKAR1A Antibody (clone 3546C2a) - LS-C184513 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 3546C2a

Anti-PRKAR1A Antibody (aa51-100) - LS-C151339 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PRKAR1A / PKR1 antibody Western Blot of Rat Spleen.

Anti-PRKAR1A Antibody (N-Terminus, APC) - LS-C226177 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKAR1A Antibody (C-Terminus) - LS-C117130 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PRKAR1A antibody LS-C117130 Western blot of Fetal Liver lysate.

Anti-PRKAR1A Antibody (N-Terminus, AP) - LS-C226178 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKAR1A Antibody (N-Terminus, Biotin) - LS-C226179 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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