PRKAR1A
| Gene Symbol | PRKAR1A |
|---|---|
| Entrez Gene | 5573 |
| Alt Symbol | ACRDYS1, ADOHR, CAR, CNC, CNC1, PKR1, PPNAD1, PRKAR1, TSE1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein kinase, cAMP-dependent, regulatory, type I, alpha |
| Other Description | Carney complex type 1|cAMP-dependent protein kinase regulatory subunit RIalpha|cAMP-dependent protein kinase type I-alpha regulatory chain|cAMP-dependent protein kinase type I-alpha regulatory subunit|protein kinase A type 1a regulatory subunit|tissue-specific extinguisher 1 |
| Swissprots | K7ER48 Q567S7 P10644 |
| Accessions | AAL05860 ABC96005 ABC96006 ABC96007 EAW89060 EAW89061 EAW89062 EAW89063 EAW89064 EAW89065 P10644 A12295 CAA01027 AA015682 AI074326 AK097580 BAG53489 AK124586 AK312307 BAG35232 AL050038 AL535889 AW732104 AY007115 BC036285 AAH36285 BC093042 AAH93042 BM928493 BU167718 BU188258 CR749311 CAH18166 DA108801 DA219203 DA413808 DQ891775 ABM82701 DQ894959 ABM85885 M18468 AAB50922 M33336 AAB50921 S54705 S54707 S54709 S54711 Y07642 CAA68925 XM_011524983 XP_011523285 XM_011524984 XP_011523286 XM_011524985 XP_011523287 NM_001276289 NP_001263218 NM_001276290 NP_001263219 NM_001278433 NP_001265362 NM_002734 NP_002725 NM_212471 NP_997636 NM_212472 NP_997637 |
| Function | Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. {ECO:0000269|PubMed:16491121, ECO:0000269|PubMed:20215566}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:23115245}. |
| Tissue Specificity | Four types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. |
| Top Pathways | Apoptosis, Insulin signaling pathway |
PKA Iα reg CRISPR/Cas9 KO Plasmid (h) - sc-402036 from Santa Cruz Biotechnology
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PKA Iα reg HDR Plasmid (h) - sc-402036-HDR from Santa Cruz Biotechnology
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PKA Iα reg Double Nickase Plasmid (h) - sc-402036-NIC from Santa Cruz Biotechnology
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PKA Iα reg Double Nickase Plasmid (h2) - sc-402036-NIC-2 from Santa Cruz Biotechnology
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PKA Iα reg CRISPR Activation Plasmid (h) - sc-402036-ACT from Santa Cruz Biotechnology
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PKA Iα reg CRISPR Activation Plasmid (h2) - sc-402036-ACT-2 from Santa Cruz Biotechnology
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PKA Iα reg Lentiviral Activation Particles (h) - sc-402036-LAC from Santa Cruz Biotechnology
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PKA Iα reg Lentiviral Activation Particles (h2) - sc-402036-LAC-2 from Santa Cruz Biotechnology
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PKA Iα reg siRNA (h) - sc-39162 from Santa Cruz Biotechnology
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PKA Iα reg shRNA Plasmid (h) - sc-39162-SH from Santa Cruz Biotechnology
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PKA Iα reg shRNA (h) Lentiviral Particles - sc-39162-V from Santa Cruz Biotechnology
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Protein Kinase A regulatory subunit I alpha RNAi - H00005573-R02 from Novus Biologicals
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Protein Kinase A regulatory subunit I alpha RNAi - H00005573-R03 from Novus Biologicals
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Protein Kinase A regulatory subunit I alpha RNAi - H00005573-R01 from Novus Biologicals
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MISSION® esiRNA - EHU071341 from Sigma-Aldrich
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MISSION® siRNA - SIHK1807 from Sigma-Aldrich
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MISSION® siRNA - SIHK1806 from Sigma-Aldrich
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MISSION® siRNA - SIHK1808 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17418 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17418 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11299 from Sigma-Aldrich
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PRKAR1A siRNA (Human) - CRH3744 from Cohesion Biosciences
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shRNA set against Human PRKAR1A (NM_002734.3) - SHH382732 from Creative biogene
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shRNA set against Human PRKAR1A(NM_002734.3) - SHG186353 from Creative biogene
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PRKAR1A shRNA Plasmid (Human) - CHH3744 from Cohesion Biosciences
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