| Gene Symbol |
YOD1
|
| Entrez Gene |
55432
|
| Alt Symbol |
DUBA8, OTUD2, PRO0907
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
YOD1 deubiquitinase
|
| Other Description |
DUBA-8|HIN-7|HIV-1-induced protease 7|OTU domain containing 2|OTU domain-containing protein 2|YOD1 OTU deubiquinating enzyme 1 homolog ( yeast)|hsHIN7|ubiquitin thioesterase OTU1
|
| Swissprots |
Q86T63 Q9P1L8 Q5VVQ5 B2RNX3 Q6ZRS6 Q5VVQ6
|
| Accessions |
EAW93509 Q5VVQ6 AK128014 BAC87233 AL833081 CAD89975 BC137166 AAI37167 BC137167 AAI37168 XM_011509725 XP_011508027 XR_247031 NM_001276320 NP_001263249 NM_018566 NP_061036
|
| Function |
Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. {ECO:0000269|PubMed:19818707, ECO:0000269|PubMed:23827681}.
|
| Top Pathways |
Protein processing in endoplasmic reticulum
|