SEMA7A

Gene Symbol SEMA7A
Entrez Gene 8482
Alt Symbol CD108, CDw108, H-SEMA-K1, H-Sema-L, JMH, SEMAK1, SEMAL
Species Human
Gene Type protein-coding
Description semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
Other Description JMH blood group antigen|John Milton Hagen blood group H-Sema K1|john-Milton-Hargen human blood group Ag|sema K1|sema L|sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A (JMH blood group)|sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, 7A|semaphorin K1|semaphorin L|semaphorin-7A|semaphorin-K1|semaphorin-L
Swissprots Q1XE81 B4DDP7 Q3MIY5 O75326 Q1XE82 F5H1S0 Q1XE83 Q1XE84
Accessions AAC34741 AAW62253 EAW99340 O75326 AF030698 AAC34261 AF069493 AAC82642 AF071542 AAC80456 AK001895 BAG50988 AK293280 BAG56808 AK312257 BAG35189 AM180445 CAJ55398 AM180446 CAJ55399 AM180447 CAJ55400 AM180448 CAJ55401 AM180449 CAJ55402 AM180450 CAJ55403 AM180451 CAJ55404 BC101643 AAI01644 BC101647 AAI01648 BU191525 DA136330 DC408557 NM_001146029 NP_001139501 NM_001146030 NP_001139502 NM_003612 NP_003603
Function Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes. {ECO:0000269|PubMed:12879062, ECO:0000269|PubMed:17377534, ECO:0000269|PubMed:17671519}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:10201933, ECO:0000269|PubMed:17671519, ECO:0000269|PubMed:9712866}; Lipid- anchor, GPI-anchor {ECO:0000269|PubMed:10201933, ECO:0000269|PubMed:17671519, ECO:0000269|PubMed:9712866}; Extracellular side {ECO:0000269|PubMed:10201933, ECO:0000269|PubMed:17671519, ECO:0000269|PubMed:9712866}. Note=Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes.
Tissue Specificity Detected in skin keratinocytes and on endothelial cells from skin blood vessels (at protein level). Expressed in fibroblasts, keratinocytes, melanocytes, placenta, testis, ovary, spleen, brain, spinal chord, lung, heart, adrenal gland, lymph nodes, thymus, intestine and kidney. {ECO:0000269|PubMed:10201933, ECO:0000269|PubMed:17671519, ECO:0000269|PubMed:9712866}.
Top Pathways Axon guidance

SEMA7A (C-6) - sc-374432 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SEMA7A (C-6): sc-374432. Western blot analysis of SEMA7A expression in ES-2 whole cell lysate.

SEMA7A (D-4) - sc-376149 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SEMA7A (D-4): sc-376149. Western blot analysis of SEMA7A expression in JAR (A) and ES-2 (B) whole cell lysates.

SEMA7A (E-18) - sc-67969 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SEMA7A (H-41) - sc-135263 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SEMA7A (H-41): sc-135263. Western blot analysis of SEMA7A expression in human erythocyte whole cell lysate.

Anti-Semaphorin 7a antibody - ab133803 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Semaphorin 7a antibody (ab133803) at 1 µg/ml + MDA-MB-435S cell lysate at 10 µg

Anti-Semaphorin 7a antibody [MEM-150] - ab8222 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MEM-150

Anti-Semaphorin 7a antibody [MEM-150] (FITC) - ab26012 from Abcam

Prices $188.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone MEM-150
Overlay histogram showing Jurkat cells stained with ab26012 (red line). The cells were fixed with 80% methanol (5 min) and incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab26012, 1.2µg/1x106 cells) for 30 min at 22ºC. Isotype control antibody (black line) was mouse IgGM FITC (2µg/1x106 cells) used under the same conditions. Acquisition of >5,000 events was performed. This antibody gave a positive signal in Jurkat cells fixed with 4% paraformaldehyde used under the same conditions.Please note that Abcam do not have any data for use of this antibody on non-fixed cells. We welcome any customer feedback.

Anti-Semaphorin 7a antibody [MEM150], prediluted (Alexa Fluor® 647) - ab187569 from Abcam

Prices $370.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone MEM150

Anti-Semaphorin 7a antibody [MM0537-99D22] - ab90242 from Abcam

Prices $370.00
Sizes 50 µg
Host Rat
Clonality Monoclonal
Clone MM0537-99D22

Anti-SEMA7A / Semaphorin 7A Antibody (clone MEM-150) - LS-C127934 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MEM-150

Anti-SEMA7A / Semaphorin 7A Antibody (aa242-507, FITC) - LS-C302339 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SEMA7A / Semaphorin 7A Antibody (clone MEM-150) - LS-C202087 from LifeSpan Bioscience

Prices $285.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MEM-150

Anti-SEMA7A / Semaphorin 7A Antibody (aa242-507, Biotin) - LS-C297760 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SEMA7A / Semaphorin 7A Antibody (clone MEM-150) - LS-C40851 from LifeSpan Bioscience

Prices $225.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MEM-150
PHA-stimulated human peripheral blood mononuclear cells stained with purified MEM-150, followed by biotinylated anti-mouse IgG and Sav-PE

Anti-SEMA7A / Semaphorin 7A Antibody (aa242-507) - LS-C296385 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant SEMA7A / Semaphorin 7A.

Anti-SEMA7A / Semaphorin 7A Antibody (clone 1G1) - LS-C139326 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1G1
Detection limit for recombinant GST tagged SEMA7A is 1 ng/ml as a capture antibody.

Anti-SEMA7A / Semaphorin 7A Antibody (aa520-569) - LS-C151697 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SEMA7A / Semaphorin 7A antibody Western Blot of 721_B lysate. Antibody Dilution: 1.0 ug/ml. SEMA7A is supported by BioGPS gene expression data to be expressed in 721_B. Antibody dilution: 1 ug/ml.

Anti-SEMA7A / Semaphorin 7A Antibody (aa178-202) - LS-C344593 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
SEMA7A Antibody western blot of human placenta and mouse testis tissue lysates (35 ug/lane). The SEMA7A antibody detected the SEMA7A protein (arrow).

Anti-SEMA7A / Semaphorin 7A Antibody (FITC) - LS-C22081 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-SEMA7A / Semaphorin 7A Antibody - LS-C22082 from LifeSpan Bioscience

Prices $590.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal

Anti-SEMA7A / Semaphorin 7A Antibody (clone MEM-150) - LS-C45906 from LifeSpan Bioscience

Prices $260.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MEM-150

Anti-SEMA7A / Semaphorin 7A Antibody (clone MEM-150, FITC) - LS-C46376 from LifeSpan Bioscience

Prices $290.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal
Clone MEM-150

Anti-SEMA7A / Semaphorin 7A Antibody (aa536-633) - LS-C126266 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Semaphorin 7A Antibody (310829) [Unconjugated] - MAB20681 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 310829

Semaphorin 7A Antibody - AF2068 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
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