| Gene Symbol |
SEMA7A
|
| Entrez Gene |
8482
|
| Alt Symbol |
CD108, CDw108, H-SEMA-K1, H-Sema-L, JMH, SEMAK1, SEMAL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
|
| Other Description |
JMH blood group antigen|John Milton Hagen blood group H-Sema K1|john-Milton-Hargen human blood group Ag|sema K1|sema L|sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A (JMH blood group)|sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, 7A|semaphorin K1|semaphorin L|semaphorin-7A|semaphorin-K1|semaphorin-L
|
| Swissprots |
Q1XE81 B4DDP7 Q3MIY5 O75326 Q1XE82 F5H1S0 Q1XE83 Q1XE84
|
| Accessions |
AAC34741 AAW62253 EAW99340 O75326 AF030698 AAC34261 AF069493 AAC82642 AF071542 AAC80456 AK001895 BAG50988 AK293280 BAG56808 AK312257 BAG35189 AM180445 CAJ55398 AM180446 CAJ55399 AM180447 CAJ55400 AM180448 CAJ55401 AM180449 CAJ55402 AM180450 CAJ55403 AM180451 CAJ55404 BC101643 AAI01644 BC101647 AAI01648 BU191525 DA136330 DC408557 NM_001146029 NP_001139501 NM_001146030 NP_001139502 NM_003612 NP_003603
|
| Function |
Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes. {ECO:0000269|PubMed:12879062, ECO:0000269|PubMed:17377534, ECO:0000269|PubMed:17671519}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:10201933, ECO:0000269|PubMed:17671519, ECO:0000269|PubMed:9712866}; Lipid- anchor, GPI-anchor {ECO:0000269|PubMed:10201933, ECO:0000269|PubMed:17671519, ECO:0000269|PubMed:9712866}; Extracellular side {ECO:0000269|PubMed:10201933, ECO:0000269|PubMed:17671519, ECO:0000269|PubMed:9712866}. Note=Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes.
|
| Tissue Specificity |
Detected in skin keratinocytes and on endothelial cells from skin blood vessels (at protein level). Expressed in fibroblasts, keratinocytes, melanocytes, placenta, testis, ovary, spleen, brain, spinal chord, lung, heart, adrenal gland, lymph nodes, thymus, intestine and kidney. {ECO:0000269|PubMed:10201933, ECO:0000269|PubMed:17671519, ECO:0000269|PubMed:9712866}.
|
| Top Pathways |
Axon guidance
|