| Gene Symbol | Car2 |
|---|---|
| Entrez Gene | 12349 |
| Alt Symbol | AI131712, CAII, Ca2, Car-2, Ltw-5, Lvtw-5 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | carbonic anhydrase 2 |
| Other Description | CA II|CA-II|carbonate dehydratase II|carbonic anhydrase II |
| Swissprots | Q9DCY9 Q7TPE1 Q9DCT3 P00920 Q6LDQ7 |
| Accessions | AAA37357 EDL05130 P00920 AK002333 BAB22019 AK002498 BAB22146 AK146015 BC044806 BC055291 AAH55291 BU946040 CD774528 K00811 AAA37356 M25944 AAA39505 U37705 U37706 XM_006530050 XP_006530113 NM_009801 NP_033931 |
| Function | Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6. {ECO:0000269|PubMed:20150244}. |
| Subcellular Location | Cytoplasm. Cell membrane {ECO:0000250}. Note=Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells (By similarity). {ECO:0000250}. |
| Top Pathways | Nitrogen metabolism, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, Gastric acid secretion, Pancreatic secretion |