Gene Symbol | Car2 |
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Entrez Gene | 12349 |
Alt Symbol | AI131712, CAII, Ca2, Car-2, Ltw-5, Lvtw-5 |
Species | Mouse |
Gene Type | protein-coding |
Description | carbonic anhydrase 2 |
Other Description | CA II|CA-II|carbonate dehydratase II|carbonic anhydrase II |
Swissprots | Q9DCY9 Q7TPE1 Q9DCT3 P00920 Q6LDQ7 |
Accessions | AAA37357 EDL05130 P00920 AK002333 BAB22019 AK002498 BAB22146 AK146015 BC044806 BC055291 AAH55291 BU946040 CD774528 K00811 AAA37356 M25944 AAA39505 U37705 U37706 XM_006530050 XP_006530113 NM_009801 NP_033931 |
Function | Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6. {ECO:0000269|PubMed:20150244}. |
Subcellular Location | Cytoplasm. Cell membrane {ECO:0000250}. Note=Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells (By similarity). {ECO:0000250}. |
Top Pathways | Nitrogen metabolism, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, Gastric acid secretion, Pancreatic secretion |
Mouse CA2 His tag protein - orb84426 from Biorbyt
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Mouse Carbonic Anhydrase II Protein - abx065008 from Abbexa
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Recombinant Mouse Carbonic Anhydrase 2, His-tagged - Car2-1191M from Creative Biomart
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Mouse Carbonic Anhydrase II / Car2 Protein (His Tag) - 50685-M08E-50 from Sino Biological
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Native Carbonic Anhydrase II (CA2) - NPA782Mu01 from Cloud-clone
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Recombinant Carbonic Anhydrase II (CA2) - RPA782Mu01 from Cloud-clone
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Recombinant Mouse Carbonic anhydrase 2(Ca2) - CSB-YP004370MO CSB-EP004370MO CSB-BP004370MO CSB-MP004370MO from Cusabio
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Native Carbonic Anhydrase II (CA2) - RPU142941 from Biomatik
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Carbonic Anhydrase II Protein (Native) - abx168597 from Abbexa
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Carbonic anhydrase 2 (Ca2), Recombinant Protein - MBS952398 from MyBioSource
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Recombinant Mouse Carbonic Anhydrase II / Car2 Protein (His tag) - PKSM040550 from Elabscience
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Recombinant Mouse CAR2 Protein - CAR2-2718M from Creative Biomart
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Carbonic Anhydrase II (CA2), Native Protein - RPU52940 from Biomatik
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Mouse Carbonic Anhydrase II / Car2 Protein (His Tag) - 50685-M08E from ABclonal
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Carbonic Anhydrase II / Car2, Recombinant Protein - MBS2546852 from MyBioSource
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