MARCH6

Gene Symbol MARCH6
Entrez Gene 10299
Alt Symbol DOA10, MARCH-VI, RNF176, TEB4
Species Human
Gene Type protein-coding
Description membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
Other Description E3 ubiquitin-protein ligase MARCH6|RING finger protein 176|doa10 homolog|membrane-associated RING finger protein 6|membrane-associated RING-CH finger protein 6|membrane-associated RING-CH protein VI
Swissprots A5PKZ4 B4DKJ2 O60337 D3DTC8 O14670 Q86X77 B4DT33
Accessions CAH05341 EAX08065 EAX08066 EAX08067 O60337 AB011169 BAA25523 AF009301 AAB66840 AF056433 AK000970 BAG50840 AK056198 AK296585 BAG59204 AK299339 BAG61341 AK300034 BAG61845 AK314686 BAG37238 AL080234 BC013761 BC039293 BC046148 AAH46148 BC111494 BC136461 AAI36462 BC136462 AAI36463 BC142679 AAI42680 BC142694 AAI42695 BX116291 DB072938 U52827 XM_011513932 XP_011512234 XM_011513933 XP_011512235 XM_011513934 XP_011512236 XM_011513935 XP_011512237 XM_011513936 XP_011512238 XM_011513937 XP_011512239 XR_925576 XR_925577 NM_001270660 NP_001257589 NM_001270661 NP_001257590 NM_005885 NP_005876
Function E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1. {ECO:0000269|PubMed:15673284, ECO:0000269|PubMed:19651899}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:15673284}; Multi-pass membrane protein {ECO:0000269|PubMed:15673284}.
Tissue Specificity Present in brain (at protein level). {ECO:0000269|PubMed:15673284}.
Top Pathways Protein processing in endoplasmic reticulum

MARCH6 (C-18) - sc-243411 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

MARCH6 (G-19) - sc-243410 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-MARCH6 antibody - ab134815 from Abcam

Prices $407.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Immunohistochemical analysis of Formalin-fixed, Paraffin embedded Human tonsil tissue labelling MARCH6 with ab134815 at 3.75µg/ml.

Anti-MARCH6 antibody - ab183533 from Abcam

Prices $357.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Detection of MARCH6 by Western Blot of Immunoprecipitate.ab183533 at 1µg/ml labeling MARCH6 in 293T whole cell lysate immunoprecipitated using ab183533 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Detection: Chemiluminescence with exposure time of 30 seconds.

Anti-MARCH6 antibody - ab77599 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-MARCH6 antibody (ab77599) at 0.2 µg/ml + human lung lysate in RIPA buffer at 35 µg

Anti-MARCH6 antibody - ab56594 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab56594 MARCH6 antibody at 1ug/ml.

Anti-MARCH6 / DOA10 Antibody (aa450-500) - LS-C290815 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human TEB4 by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP; 20% of IP loaded) from 293T cells. Antibodies: Affinity purified rabbit anti-TEB4 antibody used for IP at 6 ug/mg lysate. TEB4 was also immunoprecipitated by rabbit anti-TEB4 antibody BL15025. For blotting immunoprecipitated TEB4, was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

Anti-MARCH6 / DOA10 Antibody (aa886-898) IHC-plus™ - LS-B7361 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-MARCH6 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7361 concentration 3.75 ug/ml.

Anti-MARCH6 / DOA10 Antibody (clone 1A5) - LS-C139269 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1A5

Anti-MARCH6 / DOA10 Antibody (aa701-712) - LS-C61796 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.2 ug/ml) staining of Human Lung lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

MARCH6 Antibody - NBP2-30367 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: MARCH6 Antibody [NBP2-30367] - Whole cell lysate (50 ug) from 293T cells. Antibody used for WB at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

MARCH6 Antibody - NBP2-38987 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MARCH6 Antibody - NB100-93441 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

MARCH6 Antibody - H00010299-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: MARCH6 Antibody [H00010299-A01] - MARCH6 polyclonal antibody (A01), Lot # 051107JC01 Western Blot analysis of MARCH6 expression in MES-SA/Dx5 ( Cat # L021V1 ).

MARCH6 Antibody (2F7) - H00010299-M02 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F7
Sandwich ELISA: MARCH6 Antibody (2F7) [H00010299-M02] - Detection limit for recombinant GST tagged MARCH6 is approximately 0.3ng/ml as a capture antibody.

MARCH6 Antibody - NBP1-06088 from Novus Biologicals

Prices $229.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

MARCH6 Antibody (1A5) - H00010299-M05 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1A5

MARCH6 Polyclonal Antibody - bs-9340R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TEB4/MARCH-VI (AA 701-712) antibody produced in goat - SAB2501027 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-TEB4 / MARCH-VI (aa 701 to 712): <B>Cat. No. SAB2501027</B>: (0.2 μg/mL) staining of Human Lung lysate (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Monoclonal Anti-MARCH6 antibody produced in mouse - SAB1404812 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1A5
<B>Immunoblotting</B><BR/>Monoclonal Anti-40608: <B>Cat. No. SAB1404812</B>: Antibody concentration: 1 μg/mL. Specific band of ~36 kDa using immunogen protein lysate.

Monoclonal Anti-MARCH6 antibody produced in mouse - WH0010299M2 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F7
<B>Immunoblotting</B><BR/>Monoclonal Anti-39513, <B>Cat. No. WH0010299M2</B> used at the antibody concentration: 1 μg/mL. Specific band of ~36.01 kDa using immunogen protein lysate.

MARCH6-Antibody-monoclonal-M02 - AT2800a from Abgent, a WuXi AppTec company

Prices $315.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F7
Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (35.64 KDa) .

TEB4--MARCH-VI-aa-886-to-898-Antibody-internal-region - AF2655a from Abgent, a WuXi AppTec company

Prices $325.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

TEB4--MARCH-VI-aa-701-to-712-Antibody - AF2077a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF2077a (0.2 µg/ml) staining of Human Lung lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Goat Anti-TEB4 / MARCH-VI (aa 886 to 898) Antibody (OAEB00257) - OAEB00257 from Aviva Systems Biology

Prices $229.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
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