MARCH6

Gene Symbol	MARCH6
Entrez Gene	10299
Alt Symbol	DOA10, MARCH-VI, RNF176, TEB4
Species	Human
Gene Type	protein-coding
Description	membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase MARCH6|RING finger protein 176|doa10 homolog|membrane-associated RING finger protein 6|membrane-associated RING-CH finger protein 6|membrane-associated RING-CH protein VI
Swissprots	A5PKZ4 B4DKJ2 O60337 D3DTC8 O14670 Q86X77 B4DT33
Accessions	CAH05341 EAX08065 EAX08066 EAX08067 O60337 AB011169 BAA25523 AF009301 AAB66840 AF056433 AK000970 BAG50840 AK056198 AK296585 BAG59204 AK299339 BAG61341 AK300034 BAG61845 AK314686 BAG37238 AL080234 BC013761 BC039293 BC046148 AAH46148 BC111494 BC136461 AAI36462 BC136462 AAI36463 BC142679 AAI42680 BC142694 AAI42695 BX116291 DB072938 U52827 XM_011513932 XP_011512234 XM_011513933 XP_011512235 XM_011513934 XP_011512236 XM_011513935 XP_011512237 XM_011513936 XP_011512238 XM_011513937 XP_011512239 XR_925576 XR_925577 NM_001270660 NP_001257589 NM_001270661 NP_001257590 NM_005885 NP_005876
Function	E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1. {ECO:0000269|PubMed:15673284, ECO:0000269|PubMed:19651899}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:15673284}; Multi-pass membrane protein {ECO:0000269|PubMed:15673284}.
Tissue Specificity	Present in brain (at protein level). {ECO:0000269|PubMed:15673284}.
Top Pathways	Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MARCH6 protein fragment - ab160935 from Abcam Category Protein Source Wheat germ Species Human

MARCH6 / DOA10 Antibody Blocking Peptide - LS-E26517 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MARCH6 / DOA10 Antibody Blocking Peptide - LS-E26588 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MARCH6 Protein - H00010299-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TEB4/MARCH-VI (aa 701 to 712) blocking peptide - GTX88852-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse

TEB4/MARCH-VI (aa 886 to 898) blocking peptide - GTX88937-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse

MARCH6 Peptide - AC21-1353-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

MARCH6 Peptide - AC21-1424-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

MARCH6 / RNF176 - H00010299-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MARCH6 / RNF176 - H00010299-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MARCH6 Peptide - 46-718P from ProSci Category Peptide Species Human

TEB4 Peptide - 46-478P from ProSci Category Peptide

MARCH6 fusion protein - ag16183 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

MARCH-VI, aa701-712, Peptide - MBS633779 from MyBioSource Category Peptide Prices $340.00 Sizes 100 µg Species Mouse

TEB4/MARCH-VI, Peptide - MBS428437 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse

TEB4/MARCH-VI, Peptide - MBS426474 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse

MARCH6 Peptide, Human - M34GP09228H from Creative Peptides Category Peptide Source Synthetic. Species Human

E3 ubiquitin-protein ligase MARCH6 (MARCH6), Recombinant Protein - MBS1102223 from MyBioSource Category Protein Prices $1,375.00, $1,835.00 Sizes 1 mg (E-Coli), 1 mg (Yeast) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

MARCH6 Recombinant Protein Antigen - NBP2-58931PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

TEB4 Immunizing peptide - orb17191 from Biorbyt Category Peptide

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