| Gene Symbol |
MARCH6
|
| Entrez Gene |
10299
|
| Alt Symbol |
DOA10, MARCH-VI, RNF176, TEB4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
|
| Other Description |
E3 ubiquitin-protein ligase MARCH6|RING finger protein 176|doa10 homolog|membrane-associated RING finger protein 6|membrane-associated RING-CH finger protein 6|membrane-associated RING-CH protein VI
|
| Swissprots |
A5PKZ4 B4DKJ2 O60337 D3DTC8 O14670 Q86X77 B4DT33
|
| Accessions |
CAH05341 EAX08065 EAX08066 EAX08067 O60337 AB011169 BAA25523 AF009301 AAB66840 AF056433 AK000970 BAG50840 AK056198 AK296585 BAG59204 AK299339 BAG61341 AK300034 BAG61845 AK314686 BAG37238 AL080234 BC013761 BC039293 BC046148 AAH46148 BC111494 BC136461 AAI36462 BC136462 AAI36463 BC142679 AAI42680 BC142694 AAI42695 BX116291 DB072938 U52827 XM_011513932 XP_011512234 XM_011513933 XP_011512235 XM_011513934 XP_011512236 XM_011513935 XP_011512237 XM_011513936 XP_011512238 XM_011513937 XP_011512239 XR_925576 XR_925577 NM_001270660 NP_001257589 NM_001270661 NP_001257590 NM_005885 NP_005876
|
| Function |
E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1. {ECO:0000269|PubMed:15673284, ECO:0000269|PubMed:19651899}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:15673284}; Multi-pass membrane protein {ECO:0000269|PubMed:15673284}.
|
| Tissue Specificity |
Present in brain (at protein level). {ECO:0000269|PubMed:15673284}.
|
| Top Pathways |
Protein processing in endoplasmic reticulum
|