Gene Symbol | NPY4R |
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Entrez Gene | 5540 |
Alt Symbol | NPY4-R, PP1, PPYR1, Y4 |
Species | Human |
Gene Type | protein-coding |
Description | neuropeptide Y receptor Y4 |
Other Description | neuropeptide Y receptor type 4|pancreatic polypeptide receptor 1 |
Swissprots | Q5ISU3 Q6FH06 P50391 Q5T2X9 Q13456 |
Accessions | AAC50280 AAP23199 CAA91433 CAG26290 CAI13318 CAV09711 CAV28326 P50391 AY649985 AAV68196 AY649986 AAV68197 BC096238 AAH96238 BC099637 AAH99637 CR541950 CAG46748 U42387 AAB07759 XM_011539928 XP_011538230 XM_011539929 XP_011538231 XM_011539930 XP_011538232 XM_011539931 XP_011538233 XM_011539932 XP_011538234 XM_011539933 XP_011538235 XM_011539934 XP_011538236 XM_011539935 XP_011538237 XM_011539936 XP_011538238 XM_011539937 XP_011538239 NM_001278794 NP_001265723 NM_005972 NP_005963 |
Function | Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13- 36) > PP (31-36) > NPY free acid. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Highest levels found in brain, coronary artery and ileum. Low levels in pancreas and kidney. Detected in colon and small intestine. |
Top Pathways | Neuroactive ligand-receptor interaction |
NPY4-R CRISPR/Cas9 KO Plasmid (h) - sc-406230 from Santa Cruz Biotechnology
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NPY4-R HDR Plasmid (h) - sc-406230-HDR from Santa Cruz Biotechnology
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NPY4-R Double Nickase Plasmid (h) - sc-406230-NIC from Santa Cruz Biotechnology
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NPY4-R Double Nickase Plasmid (h2) - sc-406230-NIC-2 from Santa Cruz Biotechnology
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NPY4-R CRISPR Activation Plasmid (h) - sc-406230-ACT from Santa Cruz Biotechnology
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NPY4-R CRISPR Activation Plasmid (h2) - sc-406230-ACT-2 from Santa Cruz Biotechnology
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NPY4-R Lentiviral Activation Particles (h) - sc-406230-LAC from Santa Cruz Biotechnology
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NPY4-R Lentiviral Activation Particles (h2) - sc-406230-LAC-2 from Santa Cruz Biotechnology
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NPY4-R siRNA (h) - sc-42103 from Santa Cruz Biotechnology
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NPY4-R shRNA Plasmid (h) - sc-42103-SH from Santa Cruz Biotechnology
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NPY4-R shRNA (h) Lentiviral Particles - sc-42103-V from Santa Cruz Biotechnology
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NPY4R RNAi - H00005540-R02 from Novus Biologicals
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MISSION® esiRNA - EHU102621 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17328 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17328 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03462 from Sigma-Aldrich
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NPY4R siRNA (Human) - CRH3719 from Cohesion Biosciences
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NPY4-R CRISPR/Cas9 KO Plasmid (h2) - sc-406230-KO-2 from Santa Cruz Biotechnology
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NPY4-R HDR Plasmid (h2) - sc-406230-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human PPYR1 (NM_005972.4) - SHH381788 from Creative biogene
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shRNA set against Human PPYR1(NM_005972.4) - SHR136266 from Creative biogene
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NPY4R shRNA Plasmid (Human) - CHH3719 from Cohesion Biosciences
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PPYR1 miRNA 3'UTR clone - MiUTR1H-08204 from Creative biogene
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