| Gene Symbol |
KCNQ4
|
| Entrez Gene |
9132
|
| Alt Symbol |
DFNA2, DFNA2A, KV7.4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
potassium channel, voltage gated KQT-like subfamily Q, member 4
|
| Other Description |
potassium channel KQT-like 4|potassium channel subunit alpha KvLQT4|potassium voltage-gated channel subfamily KQT member 4|potassium voltage-gated channel, KQT-like subfamily, member 4
|
| Swissprots |
O96025 P56696
|
| Accessions |
AAD14681 EAX07197 P56696 AF105202 AAD14680 AK074957 BAG52040 CA411644 DA782056 XM_011542417 XP_011540719 XM_011542418 XP_011540720 XM_011542419 XP_011540721 XM_011542420 XP_011540722 XR_946798 XR_946799 XR_946800 NM_004700 NP_004691 NM_172163 NP_751895
|
| Function |
Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors.
|
| Subcellular Location |
Basal cell membrane; Multi-pass membrane protein. Note=Situated at the basal membrane of cochlear outer hair cells. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in the outer, but not the inner, sensory hair cells of the cochlea. Slightly expressed in heart, brain and skeletal muscle.
|
![Western Blot: KCNQ4 Overexpression Lysate (Adult Normal) [NBL1-12200] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for KCNQ4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9408_KCNQ4%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12200-img0002.jpg)
![Western Blot: Kv7.4 Overexpression Lysate (Native) [NBP2-05178] - Kv7.4 Overexpression Lysate (Native) Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for KCNQ4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5938_Kv7.4-Overexpression-Lysate-(Native)-Western-Blot-NBP2-05178-img0002.jpg)
![Western Blot: KCNQ4 Overexpression Lysate (Adult Normal) [NBP2-10019] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for KCNQ4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1543_KCNQ4%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10019-img0001.jpg)