DNMT1

Gene Symbol	DNMT1
Entrez Gene	1786
Alt Symbol	ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT
Species	Human
Gene Type	protein-coding
Description	DNA (cytosine-5-)-methyltransferase 1
Other Description	CXXC-type zinc finger protein 9|DNA (cytosine-5)-methyltransferase 1|DNA MTase HsaI|DNA methyltransferase HsaI|m.HsaI
Swissprots	P26358 A0AV63 Q9ULA2 Q9UHG5 B7ZLW6 Q9UMZ6
Accessions	AAD54507 EAW84079 EAW84080 P26358 AB209413 BAD92650 AF180682 AAF23609 AF290894 AK122759 BAG53712 AY927518 BC092517 AAH92517 BC126227 AAI26228 BC144093 AAI44094 DA653750 X63692 CAA45219 XM_011527772 XP_011526074 XM_011527773 XP_011526075 XM_011527774 XP_011526076 NM_001130823 NP_001124295 NM_001379 NP_001370
Function	Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18754681}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:12145218}.
Tissue Specificity	Ubiquitous; highly expressed in fetal tissues, heart, kidney, placenta, peripheral blood mononuclear cells, and expressed at lower levels in spleen, lung, brain, small intestine, colon, liver, and skeletal muscle. Isoform 2 is less expressed than isoform 1. {ECO:0000269|PubMed:10325416}.
Top Pathways	Cysteine and methionine metabolism, MicroRNAs in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Dnmt1 protein fragment - ab198109 from Abcam Category Protein Prices $1,281.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active mouse Dnmt1 protein fragment - ab91367 from Abcam Category Protein Prices $414.00 Sizes 300 units Source Baculovirus Species Mouse

Dnmt1 peptide - ab4920 from Abcam Category Peptide Prices $181.00 Sizes 50 µg

Human Dnmt1 full length protein - ab198140 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human Dnmt1 peptide - ab21999 from Abcam Category Peptide

Human Dnmt1 protein fragment - ab152344 from Abcam Category Protein Source Wheat germ Species Human

Mouse Dnmt1 protein fragment - ab136360 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Mouse

DNMT / DNMT1 Antibody Blocking Peptide - LS-E161 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DNMT / DNMT1 Antibody Blocking Peptide - LS-E162 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DNMT / DNMT1 Antibody Blocking Peptide - LS-E7506 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DNMT / DNMT1 Antibody Blocking Peptide - LS-E7407 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DNMT / DNMT1 Antibody Blocking Peptide - LS-E26605 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DNMT / DNMT1 Antibody Blocking Peptide - LS-E13287 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human DNMT1 Protein - H00001786-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

DNMT1 Peptide - P1649 from Novus Biologicals Category Peptide Species Human

DNMT1-Antibody-S1105-Blocking-Peptide - BP1032b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Dnmt1-Antibody-C-term-S1602-Blocking-Peptide - BP1032a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Dnmt1-Antibody-Center-S714-Blocking-Peptide - BP17415c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Phospho-Dnmt1S714-Antibody-Blocking-peptide - BP3517a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Phospho-Dnmt1S1105-Antibody-Blocking-peptide - BP3780a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

DNMT1 blocking peptide - GTX88801-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Rat, Bovine

Goat anti DNMT1 antibody Immunizing peptide - orb50335 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

DNMT1 Blocking Peptide - 33R-11018 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

Human DNMT1 Protein - abx066356 from Abbexa Category Protein Source E.coli Species Human

DNMT1 Peptide - AC21-1441-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

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