DNMT1
| Gene Symbol | DNMT1 |
|---|---|
| Entrez Gene | 1786 |
| Alt Symbol | ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT |
| Species | Human |
| Gene Type | protein-coding |
| Description | DNA (cytosine-5-)-methyltransferase 1 |
| Other Description | CXXC-type zinc finger protein 9|DNA (cytosine-5)-methyltransferase 1|DNA MTase HsaI|DNA methyltransferase HsaI|m.HsaI |
| Swissprots | P26358 A0AV63 Q9ULA2 Q9UHG5 B7ZLW6 Q9UMZ6 |
| Accessions | AAD54507 EAW84079 EAW84080 P26358 AB209413 BAD92650 AF180682 AAF23609 AF290894 AK122759 BAG53712 AY927518 BC092517 AAH92517 BC126227 AAI26228 BC144093 AAI44094 DA653750 X63692 CAA45219 XM_011527772 XP_011526074 XM_011527773 XP_011526075 XM_011527774 XP_011526076 NM_001130823 NP_001124295 NM_001379 NP_001370 |
| Function | Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18754681}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:12145218}. |
| Tissue Specificity | Ubiquitous; highly expressed in fetal tissues, heart, kidney, placenta, peripheral blood mononuclear cells, and expressed at lower levels in spleen, lung, brain, small intestine, colon, liver, and skeletal muscle. Isoform 2 is less expressed than isoform 1. {ECO:0000269|PubMed:10325416}. |
| Top Pathways | Cysteine and methionine metabolism, MicroRNAs in cancer |
Dnmt1 CRISPR/Cas9 KO Plasmid (h) - sc-400272 from Santa Cruz Biotechnology
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Dnmt1 HDR Plasmid (h) - sc-400272-HDR from Santa Cruz Biotechnology
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Dnmt1 Double Nickase Plasmid (h) - sc-400272-NIC from Santa Cruz Biotechnology
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Dnmt1 Double Nickase Plasmid (h2) - sc-400272-NIC-2 from Santa Cruz Biotechnology
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Dnmt1 CRISPR Activation Plasmid (h) - sc-400272-ACT from Santa Cruz Biotechnology
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Dnmt1 CRISPR Activation Plasmid (h2) - sc-400272-ACT-2 from Santa Cruz Biotechnology
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Dnmt1 Lentiviral Activation Particles (h) - sc-400272-LAC from Santa Cruz Biotechnology
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Dnmt1 Lentiviral Activation Particles (h2) - sc-400272-LAC-2 from Santa Cruz Biotechnology
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Dnmt1 siRNA (h2) - sc-156049 from Santa Cruz Biotechnology
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Dnmt1 shRNA Plasmid (h2) - sc-156049-SH from Santa Cruz Biotechnology
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Dnmt1 shRNA (h2) Lentiviral Particles - sc-156049-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU060601 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1486 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1455 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1486 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1455 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02053 from Sigma-Aldrich
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DNMT1 siRNA (Human) - CRH1241 from Cohesion Biosciences
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DNMT1 RNAi - H00001786-R01 from Novus Biologicals
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DNMT1 - MBS8223879 from MyBioSource
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shRNA set against Human DNMT1 (NM_001379.2) - SHH280005 from Creative biogene
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shRNA set against Human DNMT1(NM_001130823.1) - SHH012323 from Creative biogene
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DNMT1 shRNA Plasmid (Human) - CHH1241 from Cohesion Biosciences
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DNMT1 miRNA 3'UTR clone - MiUTR1H-02940 from Creative biogene
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DNMT1 miRNA 3'UTR clone - MiUTR3H-00681 from Creative biogene
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