DNMT1

Gene Symbol	DNMT1
Entrez Gene	1786
Alt Symbol	ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT
Species	Human
Gene Type	protein-coding
Description	DNA (cytosine-5-)-methyltransferase 1
Other Description	CXXC-type zinc finger protein 9|DNA (cytosine-5)-methyltransferase 1|DNA MTase HsaI|DNA methyltransferase HsaI|m.HsaI
Swissprots	P26358 A0AV63 Q9ULA2 Q9UHG5 B7ZLW6 Q9UMZ6
Accessions	AAD54507 EAW84079 EAW84080 P26358 AB209413 BAD92650 AF180682 AAF23609 AF290894 AK122759 BAG53712 AY927518 BC092517 AAH92517 BC126227 AAI26228 BC144093 AAI44094 DA653750 X63692 CAA45219 XM_011527772 XP_011526074 XM_011527773 XP_011526075 XM_011527774 XP_011526076 NM_001130823 NP_001124295 NM_001379 NP_001370
Function	Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18754681}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:12145218}.
Tissue Specificity	Ubiquitous; highly expressed in fetal tissues, heart, kidney, placenta, peripheral blood mononuclear cells, and expressed at lower levels in spleen, lung, brain, small intestine, colon, liver, and skeletal muscle. Isoform 2 is less expressed than isoform 1. {ECO:0000269|PubMed:10325416}.
Top Pathways	Cysteine and methionine metabolism, MicroRNAs in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DNMT / DNMT1 ELISA Kit (Sandwich ELISA) - LS-F7340 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.057 ng/ml Range 0.156-10 ng/ml

Mouse DNMT / DNMT1 ELISA Kit (Sandwich ELISA) - LS-F9100 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.053 ng/ml Range 0.156-10 ng/ml

Human DNMT / DNMT1 ELISA Kit (Sandwich ELISA) - LS-F11314 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

DNMT1 Colorimetric Assay Kit - KA0682 from Novus Biologicals Category Assay Kit Prices $799.00 Sizes 1 kit

DNMT1 Assay/Inhibitor Screening Assay Kit - KA1604 from Novus Biologicals Category Assay Kit Prices $519.00 Sizes 1 kit

DNMT1 Fluorometric Assay Kit - KA1516 from Novus Biologicals Category Assay Kit Prices $519.00 Sizes 1 kit

DNMT1 Assay/Inhibitor Screening Assay Kit - KA1515 from Novus Biologicals Category Assay Kit Prices $519.00 Sizes 1 kit

Rabbit anti-DNMT1 Antibody, Affinity Purified - PLA0011 from Sigma-Aldrich Prices $323.50 Sizes 100 µl

Human DNMT1 ELISA Kit - abx151332 from Abbexa Category ELISA Kit Sensitivity 0.054 ng/ml Range 0.156 ng/ml - 10 ng/ml

DNA (cytosine-5)-methyltransferase 1, DNMT1, Human, ELISA Kit - E2102h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

DNA Methyltransferase 1 (DNMT1), Human, ELISA Kit - SEJ244Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.054ng/mL Range 0.156-10ng/mL

Anserine PICP ELISA Kit - AP0022 from NeoScientific Category ELISA Kit Prices $300.00, $480.00 Sizes 100 µl, 200 µl

DNMT1, ELISA Kit - MBS2515634 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

DNMT1, ELISA Kit - MBS2515666 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of Human DNMT1 is 0.094ng/mL (The sensitivity of this assay, or lowest detectable limit (LDL) was defined as the lowest protein concentration that could be differentiated from zero). Range 0.156-10ng/mL

ELISA Kit for DNA Methyltransferase 1 (DNMT1) - SEJ244Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.057ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for DNA Methyltransferase 1 (DNMT1) - SEJ244Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.053ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for DNA Methyltransferase 1 (DNMT1) - SEJ244Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.057ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Bovine DNMT / DNMT1 ELISA Kit (Custom ELISA) - LS-F19247 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Mouse DNMT / DNMT1 ELISA Kit (Custom ELISA) - LS-F19246 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Rat DNMT / DNMT1 ELISA Kit (Custom ELISA) - LS-F19245 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Chicken DNMT / DNMT1 ELISA Kit (Custom ELISA) - LS-F19248 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

DNMT1 Assay Kit - KA0682 from Acris Antibodies Category Assay Kit Prices $650.00 Sizes 1 kit

Human DNMT1(DNA Methyltransferase 1) ELISA Kit - E-EL-H5426 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 0.1 ng/mL Range 0.16~10 ng/mL

ELISA Kit for DNA Methyltransferase 1 (DNMT1) - SEJ244Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.059ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human DNMT / DNMT1 ELISA Kit (Sandwich ELISA) - LS-F21287 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 0.094 ng/ml Range 0.156-10 ng/ml

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