| Gene Symbol |
TICRR
|
| Entrez Gene |
90381
|
| Alt Symbol |
C15orf42, SLD3, Treslin
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TOPBP1-interacting checkpoint and replication regulator
|
| Other Description |
topBP1-interacting replication-stimulating protein|treslin
|
| Swissprots |
Q7Z2Z1 Q9BU55 Q8NCH6 Q8N4X8 B3KVV9 D3IUT4 B2RE07
|
| Accessions |
CAF86784 EAX02056 Q7Z2Z1 AK074727 BAC11165 AK123612 BAG53921 AK315750 BAG38104 AW627706 BC002881 AAH02881 BC033209 AAH33209 BX538335 CAD98102 CN285632 DR731357 DR731358 GQ227787 ADC30133 XM_011522161 XP_011520463 XM_011522162 XP_011520464 NM_001308025 NP_001294954 NM_152259 NP_689472
|
| Function |
Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre- initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:20080954}. Note=Associates with chromatin.
|