Gene Symbol | THRSP |
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Entrez Gene | 7069 |
Alt Symbol | LPGP1, Lpgp, S14, SPOT14, THRP |
Species | Human |
Gene Type | protein-coding |
Description | thyroid hormone responsive |
Other Description | SPOT14 homolog|lipogenic protein 1|spot 14 protein|thyroid hormone responsive (SPOT14 homolog, rat)|thyroid hormone responsive SPOT14|thyroid hormone-inducible hepatic protein |
Swissprots | B2R4W7 Q92748 |
Accessions | CAA69685 EAW75045 Q92748 AI480357 AI749106 AK311975 BAG34914 BC031989 AAH31989 BG674197 BP317892 CB122257 EU447014 ABZ92543 NM_003251 NP_003242 |
Function | Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA (By similarity). May function as transcriptional coactivator. May modulate the transcription factor activity of THRB. {ECO:0000250, ECO:0000269|PubMed:17418816, ECO:0000269|PubMed:18299245}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:18299245}. Cytoplasm {ECO:0000269|PubMed:18299245}. |
Tissue Specificity | Mainly expressed in tissues that synthesize triglycerides. |
Spot 14 CRISPR/Cas9 KO Plasmid (h) - sc-407735 from Santa Cruz Biotechnology
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Spot 14 HDR Plasmid (h) - sc-407735-HDR from Santa Cruz Biotechnology
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Spot 14 Double Nickase Plasmid (h) - sc-407735-NIC from Santa Cruz Biotechnology
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Spot 14 Double Nickase Plasmid (h2) - sc-407735-NIC-2 from Santa Cruz Biotechnology
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Spot 14 CRISPR Activation Plasmid (h) - sc-407735-ACT from Santa Cruz Biotechnology
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Spot 14 CRISPR Activation Plasmid (h2) - sc-407735-ACT-2 from Santa Cruz Biotechnology
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Spot 14 Lentiviral Activation Particles (h) - sc-407735-LAC from Santa Cruz Biotechnology
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Spot 14 Lentiviral Activation Particles (h2) - sc-407735-LAC-2 from Santa Cruz Biotechnology
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Spot 14 siRNA (h) - sc-63058 from Santa Cruz Biotechnology
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Spot 14 shRNA Plasmid (h) - sc-63058-SH from Santa Cruz Biotechnology
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Spot 14 shRNA (h) Lentiviral Particles - sc-63058-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU058381 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21325 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21325 from Sigma-Aldrich
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THRSP siRNA (Human) - CRH4838 from Cohesion Biosciences
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THRSP - MBS8219608 from MyBioSource
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shRNA set against Human THRSP (NM_003251.3) - SHH427048 from Creative biogene
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Human THRSP siRNA - orb265340 from Biorbyt
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THRSP shRNA Plasmid (Human) - CHH4838 from Cohesion Biosciences
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THRSP miRNA 3'UTR clone - MiUTR4H-TG08965 from Creative biogene
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