| Gene Symbol |
SLC46A1
|
| Entrez Gene |
113235
|
| Alt Symbol |
G21, HCP1, PCFT
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 46 (folate transporter), member 1
|
| Other Description |
heme carrier protein 1|proton-coupled folate transporter
|
| Swissprots |
Q96FL0 Q86T92 Q8TEG3 Q96NT5 Q1HE20
|
| Accessions |
ABF47092 CAH05421 EAW51085 EAW51086 EAW51087 EAW51088 EAW51089 Q96NT5 AK054669 BAB70789 AK074161 BAB84987 AK097194 AK295883 BAG58679 AL832613 CAD89945 BC010691 AAH10691 BC022100 BC065365 DA013269 DA188147 DA436636 DA527125 DB121588 JF432839 ADZ16056 XM_005277786 XP_005277843 NM_001242366 NP_001229295 NM_080669 NP_542400
|
| Function |
Has been shown to act both as an intestinal proton- coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme. {ECO:0000269|PubMed:17129779, ECO:0000269|PubMed:17156779, ECO:0000269|PubMed:17446347, ECO:0000269|PubMed:17475902}.
|
| Subcellular Location |
Apical cell membrane; Multi-pass membrane protein. Cytoplasm {ECO:0000250}. Note=Localizes to the apical membrane of intestinal cells in iron-deficient cells, while it resides in the cytoplasm in iron-replete cells. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in kidney, liver, placenta, small intestine, spleen, retina and retinal pigment epithelium. Lower levels found in colon and testis. Very low levels in brain, lung, stomach, heart and muscle. In intestine, expressed in duodenum with lower levels in jejunum, ileum, cecum, rectum and segments of the colon. {ECO:0000269|PubMed:17129779, ECO:0000269|PubMed:17335806}.
|
| Top Pathways |
Mineral absorption, Vitamin digestion and absorption
|