SLC46A1

Gene Symbol SLC46A1
Entrez Gene 113235
Alt Symbol G21, HCP1, PCFT
Species Human
Gene Type protein-coding
Description solute carrier family 46 (folate transporter), member 1
Other Description heme carrier protein 1|proton-coupled folate transporter
Swissprots Q96FL0 Q86T92 Q8TEG3 Q96NT5 Q1HE20
Accessions ABF47092 CAH05421 EAW51085 EAW51086 EAW51087 EAW51088 EAW51089 Q96NT5 AK054669 BAB70789 AK074161 BAB84987 AK097194 AK295883 BAG58679 AL832613 CAD89945 BC010691 AAH10691 BC022100 BC065365 DA013269 DA188147 DA436636 DA527125 DB121588 JF432839 ADZ16056 XM_005277786 XP_005277843 NM_001242366 NP_001229295 NM_080669 NP_542400
Function Has been shown to act both as an intestinal proton- coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme. {ECO:0000269|PubMed:17129779, ECO:0000269|PubMed:17156779, ECO:0000269|PubMed:17446347, ECO:0000269|PubMed:17475902}.
Subcellular Location Apical cell membrane; Multi-pass membrane protein. Cytoplasm {ECO:0000250}. Note=Localizes to the apical membrane of intestinal cells in iron-deficient cells, while it resides in the cytoplasm in iron-replete cells. {ECO:0000250}.
Tissue Specificity Expressed in kidney, liver, placenta, small intestine, spleen, retina and retinal pigment epithelium. Lower levels found in colon and testis. Very low levels in brain, lung, stomach, heart and muscle. In intestine, expressed in duodenum with lower levels in jejunum, ileum, cecum, rectum and segments of the colon. {ECO:0000269|PubMed:17129779, ECO:0000269|PubMed:17335806}.
Top Pathways Mineral absorption, Vitamin digestion and absorption

HCP1 CRISPR/Cas9 KO Plasmid (h) - sc-417354 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HCP1 HDR Plasmid (h) - sc-417354-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HCP1 Double Nickase Plasmid (h) - sc-417354-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HCP1 Double Nickase Plasmid (h2) - sc-417354-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HCP1 CRISPR Activation Plasmid (h) - sc-417354-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HCP1 CRISPR Activation Plasmid (h2) - sc-417354-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HCP1 Lentiviral Activation Particles (h) - sc-417354-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HCP1 Lentiviral Activation Particles (h2) - sc-417354-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HCP1 siRNA (h) - sc-72314 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HCP1 shRNA Plasmid (h) - sc-72314-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HCP1 shRNA (h) Lentiviral Particles - sc-72314-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU109371 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® esiRNA - EHU079701 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2526 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2526 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SLC46A1 siRNA (Human) - CRJ4318 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SLC46A1 - MBS8217337 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SLC46A1 (NM_080669.4) - SHH411428 from Creative biogene

Category siRNA
Species Reactivities Human

Human SLC46A1 siRNA - orb274819 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SLC46A1 shRNA Plasmid (Human) - CHJ4318 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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