SLC46A1

Gene Symbol SLC46A1
Entrez Gene 113235
Alt Symbol G21, HCP1, PCFT
Species Human
Gene Type protein-coding
Description solute carrier family 46 (folate transporter), member 1
Other Description heme carrier protein 1|proton-coupled folate transporter
Swissprots Q96FL0 Q86T92 Q8TEG3 Q96NT5 Q1HE20
Accessions ABF47092 CAH05421 EAW51085 EAW51086 EAW51087 EAW51088 EAW51089 Q96NT5 AK054669 BAB70789 AK074161 BAB84987 AK097194 AK295883 BAG58679 AL832613 CAD89945 BC010691 AAH10691 BC022100 BC065365 DA013269 DA188147 DA436636 DA527125 DB121588 JF432839 ADZ16056 XM_005277786 XP_005277843 NM_001242366 NP_001229295 NM_080669 NP_542400
Function Has been shown to act both as an intestinal proton- coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme. {ECO:0000269|PubMed:17129779, ECO:0000269|PubMed:17156779, ECO:0000269|PubMed:17446347, ECO:0000269|PubMed:17475902}.
Subcellular Location Apical cell membrane; Multi-pass membrane protein. Cytoplasm {ECO:0000250}. Note=Localizes to the apical membrane of intestinal cells in iron-deficient cells, while it resides in the cytoplasm in iron-replete cells. {ECO:0000250}.
Tissue Specificity Expressed in kidney, liver, placenta, small intestine, spleen, retina and retinal pigment epithelium. Lower levels found in colon and testis. Very low levels in brain, lung, stomach, heart and muscle. In intestine, expressed in duodenum with lower levels in jejunum, ileum, cecum, rectum and segments of the colon. {ECO:0000269|PubMed:17129779, ECO:0000269|PubMed:17335806}.
Top Pathways Mineral absorption, Vitamin digestion and absorption

HCP1 (B-4) - sc-393460 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HCP1 (B-4): sc-393460. Western blot analysis of HCP1 expression in T24 (A), HISM (B) and NIH/3T3 (C) whole cell lysates.

HCP1 (C-15) - sc-54204 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HCP1 (C-15): sc-54204. Western blot analysis of HCP1 expression in HISM (A) and T24 (B) whole cell lysates.

HCP1 (M-15) - sc-54207 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HCP1 (M-15): sc-54207. Western blot analysis of HCP1 expression in T24 whole cell lysate.

HCP1 (H-197) - sc-134997 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-HCP1 antibody - ab25134 from Abcam

Prices $380.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HCP1 antibody (ab25134) at 1 µg/mlLane 1 : Liver (Rat) Tissue Lysate Lane 2 : Spleen (Rat) Tissue LysateLane 3 : Heart (Rat) Tissue LysateLane 4 : Kidney (Mouse) Tissue LysateLane 5 : NIH 3T3 (Mouse embryonic fibroblast cell line) Whole Cell Lysate Lysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-HCP1 antibody - ab118384 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-HCP1 antibody (ab118384) at 0.3 µg/ml (for 1 hour) + Human Liver lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-HCP1 antibody - ab98043 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-HCP1 antibody (ab98043) at 1 µg/ml + OVCAR-3 cell lysate at 10 µg

Anti-HCP1 antibody - ab112004 from Abcam

Prices $407.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab112004, at 3.75µg/ml, staining HCP1 in formalin-fixed, paraffin-embedded Human Placenta tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-HCP1 antibody - C-terminal - ab183350 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC46A1 / HCP1 Antibody (C-Terminus) - LS-C144951 from LifeSpan Bioscience

Prices $285.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC46A1 / HCP1 Antibody (N-Terminus) - LS-C107642 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SLC46A1 / HCP1 antibody LS-C107642 Western blot of OVCAR-3 cell lysate.

Anti-SLC46A1 / HCP1 Antibody (aa234-247) - LS-C139787 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
SLC46A1 antibody (0.3 ug/ml) staining of Human Liver lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-SLC46A1 / HCP1 Antibody (aa225-275) - LS-C291059 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human SLC46A1 by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP; 20% of IP loaded) prepared using NETN buffer from HeLa cells. Antibodies: Affinity purified rabbit anti-SLC46A1 antibody used for IP at 6 ug per reaction. SLC46A1 was also immunoprecipitated by rabbit anti-SLC46A1 antibody BL16362. For blotting immunoprecipitated SLC46A1, was used at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

Anti-SLC46A1 / HCP1 Antibody (aa57-70) IHC-plus™ - LS-B3827 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-SLC46A1 / HCP1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3827 concentration 3.75 ug/ml.

HCP1 Antibody - NBP1-52548 from Novus Biologicals

Prices $369.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Immunohistochemistry-Paraffin: HCP1 Antibody [NBP1-52548] - Analysis of anti-SLC46A1 / HCP1 antibody with human placenta at concentration 3.75 ug/ml.

Anti-SLC46A1 antibody produced in goat - SAB2501844 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-SLC46A1: <B>Cat. No. SAB2501844</B>: (0.3 μg/mL) staining of Human Liver lysate (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-SLC46A1, (N-terminal) antibody produced in rabbit - SAB2104833 from Sigma-Aldrich

Prices $347.50
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-SLC46A1, antibody produced in rabbit: <B>Cat. No. SAB2104833</B>: Immunoblotting analysis of SLC46A1 in OVCAR-3 cell lysate with SLC46A1 anitbody at 1 μg/mL.

SLC46A1 antibody - N-terminal region (ARP44088_P050) - ARP44088_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SLC46A1--PCFT-aa233-247-Antibody-internal-region - AF3552a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF3552a (0.3 µg/ml) staining of Human Liver lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Goat anti-SLC46A1 / PCFT (aa233-247) middle region Antibody (OAEB02804) - OAEB02804 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

SLC46A1 antibody - 70R-6536 from Fitzgerald

Host Rabbit
Clonality Polyclonal

Anti-HCP1 Antibody - AC21-2510 from Abcore

Prices $359.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-HCP1 Antibody (AMCA) - AC21-2510-01 from Abcore

Prices $495.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-HCP1 Antibody (AP) - AC21-2510-02 from Abcore

Prices $505.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-HCP1 Antibody (APC) - AC21-2510-03 from Abcore

Prices $515.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
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