Gene Symbol | GPX2 |
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Entrez Gene | 2877 |
Alt Symbol | GI-GPx, GPRP, GPRP-2, GPx-2, GPx-GI, GSHPX-GI, GSHPx-2 |
Species | Human |
Gene Type | protein-coding |
Description | glutathione peroxidase 2 |
Other Description | gastrointestinal glutathione peroxidase|glutathione peroxidase 2 (gastrointestinal)|glutathione peroxidase-related protein 2 |
Swissprots | Q6PJ52 Q9NRP9 P18283 Q8WWI7 |
Accessions | AAF74026 AAV31780 EAW80889 EAW80890 EAW80891 EAW80892 P18283 AK225871 BC005277 AAH05277 BC016756 AAH16756 BC022820 AAH22820 BC039850 BC046164 BC067221 AAH67221 BF207526 BG429974 X53463 CAB43534 X68314 CAA48394 NM_002083 NP_002074 NR_046320 NR_046321 |
Function | Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors. |
Subcellular Location | Cytoplasm. Note=Mainly cytoplasmic. |
Tissue Specificity | Mostly in liver and gastrointestinal tract, not found in heart or kidney. |
Top Pathways | Thyroid hormone synthesis, Glutathione metabolism, Arachidonic acid metabolism |
GPx-2 CRISPR/Cas9 KO Plasmid (h) - sc-406827 from Santa Cruz Biotechnology
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GPx-2 HDR Plasmid (h) - sc-406827-HDR from Santa Cruz Biotechnology
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GPx-2 Double Nickase Plasmid (h) - sc-406827-NIC from Santa Cruz Biotechnology
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GPx-2 Double Nickase Plasmid (h2) - sc-406827-NIC-2 from Santa Cruz Biotechnology
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GPx-2 CRISPR Activation Plasmid (h) - sc-406827-ACT from Santa Cruz Biotechnology
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GPx-2 CRISPR Activation Plasmid (h2) - sc-406827-ACT-2 from Santa Cruz Biotechnology
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GPx-2 Lentiviral Activation Particles (h) - sc-406827-LAC from Santa Cruz Biotechnology
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GPx-2 Lentiviral Activation Particles (h2) - sc-406827-LAC-2 from Santa Cruz Biotechnology
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GPx-2 siRNA (h) - sc-62415 from Santa Cruz Biotechnology
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GPx-2 shRNA Plasmid (h) - sc-62415-SH from Santa Cruz Biotechnology
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GPx-2 shRNA (h) Lentiviral Particles - sc-62415-V from Santa Cruz Biotechnology
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Glutathione Peroxidase 2/GPX2 RNAi - H00002877-R01 from Novus Biologicals
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MISSION® esiRNA - EHU047641 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9646 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9646 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02272 from Sigma-Aldrich
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GPX2 siRNA (Human) - CRH1934 from Cohesion Biosciences
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GPX2 - MBS8218584 from MyBioSource
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shRNA set against Human GPX2 (NM_002083.3) - SHH307374 from Creative biogene
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GPx-2 CRISPR/Cas9 KO Plasmid (h2) - sc-406827-KO-2 from Santa Cruz Biotechnology
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GPx-2 HDR Plasmid (h2) - sc-406827-HDR-2 from Santa Cruz Biotechnology
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Human GPX2 siRNA - orb262436 from Biorbyt
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GPX2 shRNA Plasmid (Human) - CHH1934 from Cohesion Biosciences
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