Gene Symbol | BCCIP |
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Entrez Gene | 56647 |
Alt Symbol | TOK-1, TOK1 |
Species | Human |
Gene Type | protein-coding |
Description | BRCA2 and CDKN1A interacting protein |
Other Description | BCCIPalpha|BCCIPbeta|BRCA2 and CDKN1A-interacting protein|BRCA2 and Cip1/p21 interacting protein|TOK-1alpha|TOK-1beta|cdk inhibitor p21 binding protein|p21- and CDK-associated protein 1|protein TOK-1 |
Swissprots | Q96GC4 Q9P287 Q9P288 B3KP45 Q8ND15 |
Accessions | AAL55436 AAL55438 EAW49218 EAW49219 EAW49220 Q9P287 AA806484 AB040450 BAA92927 AB040451 BAA92928 AK055691 BAG51557 AK092054 AK300767 BAG62432 AK304529 BAG65330 AL834458 CAD39118 AY064248 AAL55439 AY064249 AAL55440 AY092061 BC009771 AAH09771 BM741863 BM905542 BM974496 BQ008485 NM_016567 NP_057651 NM_078468 NP_510868 NM_078469 NP_510869 |
Function | May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ). {ECO:0000269|PubMed:10878006, ECO:0000269|PubMed:14726710, ECO:0000269|PubMed:15539944, ECO:0000269|PubMed:15713648, ECO:0000269|PubMed:17947333}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:10878006, ECO:0000269|PubMed:11313963, ECO:0000269|PubMed:15713648}. Note=Colocalizes with BRCA2 in discrete nuclear foci. |
Tissue Specificity | Expressed at high levels in testis and skeletal muscle and at lower levels in brain, heart, kidney, liver, lung, ovary, pancreas, placenta, and spleen. {ECO:0000269|PubMed:10878006, ECO:0000269|PubMed:11313963}. |
Human BCCIP full length protein - ab180349 from Abcam
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Human BCCIP full length protein - ab127216 from Abcam
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BCCIP Partial Recombinant Protein - H00056647-Q01 from Novus Biologicals
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BCCIP Recombinant Protein - H00056647-P01 from Novus Biologicals
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Human BCCIP protein (GST Tag) - orb138251 from Biorbyt
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BCCIP protein (His tag) - 80R-3881 from Fitzgerald
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BCCIP / TOK1 (1-314, His-tag) - AR51568PU-N from Acris Antibodies
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BCCIP / TOK1 (1-314, His-tag) - AR51568PU-S from Acris Antibodies
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BCCIP / TOK1 - H00056647-P01-10 from Acris Antibodies
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BCCIP / TOK1 - H00056647-P01-25 from Acris Antibodies
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BCCIP / TOK1 - H00056647-Q01-10 from Acris Antibodies
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BCCIP / TOK1 - H00056647-Q01-25 from Acris Antibodies
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BCCIP, 1-314aa, Human, His tag, E.coli - 01-P2748 from ARP American Research Products
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BCCIP fusion protein - Ag8934 from Proteintech Group
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BCCIP fusion protein - ag9187 from Proteintech Group
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Recombinant Human BCCIP, GST-tagged - BCCIP-10171H from Creative Biomart
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Recombinant Human BCCIP, His-tagged - BCCIP-255H from Creative Biomart
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Human BRCA2 / BCCIP Protein (His & GST Tag) - 14442-H20B-20 from Sino Biological
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Human BRCA2 / BCCIP Protein - 14442-HNCB-20 from Sino Biological
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Recombinant Human BRCA2 and CDKN1A-interacting protein(BCCIP) - CSB-YP882175HU CSB-EP882175HU CSB-BP882175HU CSB-MP882175HU from Cusabio
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BCCIP, 1-314aa, Human, His tag, E.coli - ATGP2748 from ATGen
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BCCIP / TOK1 (transcript variant B) - TP303061 from Acris Antibodies
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Recombinant Human BCCIP Protein, His&GST-tagged - BCCIP-622H from Creative Biomart
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Recombinant Human BCCIP Protein - BCCIP-623H from Creative Biomart
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Human BCCIP protein - orb259804 from Biorbyt
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