BCCIP
| Gene Symbol | BCCIP |
|---|---|
| Entrez Gene | 56647 |
| Alt Symbol | TOK-1, TOK1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | BRCA2 and CDKN1A interacting protein |
| Other Description | BCCIPalpha|BCCIPbeta|BRCA2 and CDKN1A-interacting protein|BRCA2 and Cip1/p21 interacting protein|TOK-1alpha|TOK-1beta|cdk inhibitor p21 binding protein|p21- and CDK-associated protein 1|protein TOK-1 |
| Swissprots | Q96GC4 Q9P287 Q9P288 B3KP45 Q8ND15 |
| Accessions | AAL55436 AAL55438 EAW49218 EAW49219 EAW49220 Q9P287 AA806484 AB040450 BAA92927 AB040451 BAA92928 AK055691 BAG51557 AK092054 AK300767 BAG62432 AK304529 BAG65330 AL834458 CAD39118 AY064248 AAL55439 AY064249 AAL55440 AY092061 BC009771 AAH09771 BM741863 BM905542 BM974496 BQ008485 NM_016567 NP_057651 NM_078468 NP_510868 NM_078469 NP_510869 |
| Function | May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ). {ECO:0000269|PubMed:10878006, ECO:0000269|PubMed:14726710, ECO:0000269|PubMed:15539944, ECO:0000269|PubMed:15713648, ECO:0000269|PubMed:17947333}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:10878006, ECO:0000269|PubMed:11313963, ECO:0000269|PubMed:15713648}. Note=Colocalizes with BRCA2 in discrete nuclear foci. |
| Tissue Specificity | Expressed at high levels in testis and skeletal muscle and at lower levels in brain, heart, kidney, liver, lung, ovary, pancreas, placenta, and spleen. {ECO:0000269|PubMed:10878006, ECO:0000269|PubMed:11313963}. |
TOK-1 CRISPR/Cas9 KO Plasmid (h) - sc-406452 from Santa Cruz Biotechnology
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TOK-1 HDR Plasmid (h) - sc-406452-HDR from Santa Cruz Biotechnology
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TOK-1 Double Nickase Plasmid (h) - sc-406452-NIC from Santa Cruz Biotechnology
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TOK-1 Double Nickase Plasmid (h2) - sc-406452-NIC-2 from Santa Cruz Biotechnology
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TOK-1 CRISPR Activation Plasmid (h) - sc-406452-ACT from Santa Cruz Biotechnology
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TOK-1 CRISPR Activation Plasmid (h2) - sc-406452-ACT-2 from Santa Cruz Biotechnology
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TOK-1 Lentiviral Activation Particles (h) - sc-406452-LAC from Santa Cruz Biotechnology
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TOK-1 Lentiviral Activation Particles (h2) - sc-406452-LAC-2 from Santa Cruz Biotechnology
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TOK-1 siRNA (h) - sc-106626 from Santa Cruz Biotechnology
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TOK-1 shRNA Plasmid (h) - sc-106626-SH from Santa Cruz Biotechnology
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TOK-1 shRNA (h) Lentiviral Particles - sc-106626-V from Santa Cruz Biotechnology
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BCCIP RNAi - H00056647-R01 from Novus Biologicals
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BCCIP RNAi - H00056647-R02 from Novus Biologicals
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MISSION® esiRNA - EHU076291 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3898 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3898 from Sigma-Aldrich
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BCCIP siRNA (Human) - CRJ1155 from Cohesion Biosciences
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BCCIP RNAi - H00056647-R03 from Novus Biologicals
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BCCIP - MBS8238672 from MyBioSource
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TOK-1 CRISPR/Cas9 KO Plasmid (h2) - sc-406452-KO-2 from Santa Cruz Biotechnology
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TOK-1 HDR Plasmid (h2) - sc-406452-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human BCCIP (NM_016567.3) - SHH245774 from Creative biogene
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BCCIP shRNA Plasmid (Human) - CHJ1155 from Cohesion Biosciences
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BCCIP miRNA 3'UTR clone - MiUTR3H-12196 from Creative biogene
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BCCIP miRNA 3'UTR clone - MiUTR3H-12197 from Creative biogene
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