GRK4

Gene Symbol	GRK4
Entrez Gene	2868
Alt Symbol	GPRK2L, GPRK4, GRK4a, IT11
Species	Human
Gene Type	protein-coding
Description	G protein-coupled receptor kinase 4
Other Description	ITI1
Swissprots	Q53EQ8 Q14453 Q15315 Q14725 Q13294 O00642 Q15314 Q13293 Q17RH6 Q15313 Q13295 P32298 O00641 Q15316
Accessions	AAB04045 AAC50409 AAC50410 AAC50411 AAC50412 CAA92341 EAW82479 EAW82480 EAW82481 EAW82482 EAW82483 EAW82484 EAW82485 P32298 AK223581 BAD97301 AK292390 BAF85079 AK293569 BAG57040 BC027597 BC039732 BC117320 AAI17321 BI465220 BM725978 HQ258463 ADR83217 U33054 AAC50406 U33055 AAC50407 U33056 AAC50408 X75897 CAA53506 X97879 CAA66468 X97880 CAA66469 X97881 CAA66470 X98118 CAA66802 XM_005247962 XP_005248019 XM_006713880 XP_006713943 XM_011513447 XP_011511749 XM_011513448 XP_011511750 XM_011513449 XP_011511751 XM_011513450 XP_011511752 XM_011513451 XP_011511753 XM_011513452 XP_011511754 XM_011513453 XP_011511755 XM_011513454 XP_011511756 XM_011513455 XP_011511757 XM_011513456 XP_011511758 XM_011513457 XP_011511759 XR_924941 XR_924943 NM_001004056 NP_001004056 NM_001004057 NP_001004057 NM_005307 NP_005298 NM_182982 NP_892027
Function	Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. {ECO:0000269|PubMed:19520868, ECO:0000269|PubMed:8626439}.
Subcellular Location	Cytoplasm. Cytoplasm, cell cortex. Note=Both at the cell surface and dispersed in the cytoplasm under basal conditions. Receptor stimulation results in the internalization of GRK4 to the perinuclear area, where colocalization with DRD3 is observed strongly at 5 and 15 minutes. DRD3 and GRK4 colocalize in lipid rafts of renal proximal tubule cells.
Tissue Specificity	Isoform 1, isoform 2, isoform 3, and isoform 4 are expressed in testis. Isoform 4 is expressed in myometrium. {ECO:0000269|PubMed:16636192, ECO:0000269|PubMed:8626439}.
Top Pathways	Endocytosis, Chemokine signaling pathway, Morphine addiction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human GRK4 protein fragment - ab158570 from Abcam Category Protein Source Wheat germ Species Human

GRK4 Antibody Blocking Peptide - LS-E19351 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GRK4 Antibody Blocking Peptide - LS-E19350 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human GRK4 Protein - H00002868-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

GRK4 Peptide - P2089 from Novus Biologicals Category Peptide Species Human

GRK4-Antibody-C-term-Blocking-Peptide - BP7006a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GRK4 Blocking Peptide - 33R-7734 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

GRK4 Blocking Peptide - 33R-2524 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

GRK4 - H00002868-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

GRK4 - H00002868-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

GRK4 - P5555 from Acris Antibodies Category Protein Prices $1,010.00 Sizes 5 µg Species Human

Recombinant G Protein Coupled Receptor Kinase 4 (GRK4) - RPC193Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant G Protein Coupled Receptor Kinase 4 (GRK4) - RPC193Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human G protein-coupled receptor kinase 4(GRK4) - CSB-YP009925HU CSB-EP009925HU CSB-BP009925HU CSB-MP009925HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

GRK 4 (81-150) - sc-4451 WB from Santa Cruz Biotechnology Category Protein Prices $88.00 Sizes 10 µg/0.1 ml Species Human

GRK4 (transcript variant 1) - TP316602 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

GRK4 Recombinant Protein Antigen - NBP2-37960PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

GRK4 Peptide, Human - M34GP06670H from Creative Peptides Category Peptide Source Synthetic. Species Human

G protein-coupled receptor kinase 4 (GRK4), Recombinant Protein - MBS950210 from MyBioSource Category Protein Prices $1,375.00, $1,375.00, $1,595.00, $1,595.00, $2,295.00, $2,295.00, $2,760.00, $2,760.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

GRK4 Recombinant Protein (OPCD03685) - OPCD03685 from Aviva Systems Biology Category Protein Source E.coli Species Human

GRK4 Recombinant Protein Antigen - NBP2-55415PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

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