GRK4

Gene Symbol GRK4
Entrez Gene 2868
Alt Symbol GPRK2L, GPRK4, GRK4a, IT11
Species Human
Gene Type protein-coding
Description G protein-coupled receptor kinase 4
Other Description ITI1
Swissprots Q53EQ8 Q14453 Q15315 Q14725 Q13294 O00642 Q15314 Q13293 Q17RH6 Q15313 Q13295 P32298 O00641 Q15316
Accessions AAB04045 AAC50409 AAC50410 AAC50411 AAC50412 CAA92341 EAW82479 EAW82480 EAW82481 EAW82482 EAW82483 EAW82484 EAW82485 P32298 AK223581 BAD97301 AK292390 BAF85079 AK293569 BAG57040 BC027597 BC039732 BC117320 AAI17321 BI465220 BM725978 HQ258463 ADR83217 U33054 AAC50406 U33055 AAC50407 U33056 AAC50408 X75897 CAA53506 X97879 CAA66468 X97880 CAA66469 X97881 CAA66470 X98118 CAA66802 XM_005247962 XP_005248019 XM_006713880 XP_006713943 XM_011513447 XP_011511749 XM_011513448 XP_011511750 XM_011513449 XP_011511751 XM_011513450 XP_011511752 XM_011513451 XP_011511753 XM_011513452 XP_011511754 XM_011513453 XP_011511755 XM_011513454 XP_011511756 XM_011513455 XP_011511757 XM_011513456 XP_011511758 XM_011513457 XP_011511759 XR_924941 XR_924943 NM_001004056 NP_001004056 NM_001004057 NP_001004057 NM_005307 NP_005298 NM_182982 NP_892027
Function Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. {ECO:0000269|PubMed:19520868, ECO:0000269|PubMed:8626439}.
Subcellular Location Cytoplasm. Cytoplasm, cell cortex. Note=Both at the cell surface and dispersed in the cytoplasm under basal conditions. Receptor stimulation results in the internalization of GRK4 to the perinuclear area, where colocalization with DRD3 is observed strongly at 5 and 15 minutes. DRD3 and GRK4 colocalize in lipid rafts of renal proximal tubule cells.
Tissue Specificity Isoform 1, isoform 2, isoform 3, and isoform 4 are expressed in testis. Isoform 4 is expressed in myometrium. {ECO:0000269|PubMed:16636192, ECO:0000269|PubMed:8626439}.
Top Pathways Endocytosis, Chemokine signaling pathway, Morphine addiction

GRK 4 CRISPR/Cas9 KO Plasmid (h) - sc-402816 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GRK 4 HDR Plasmid (h) - sc-402816-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GRK 4 Double Nickase Plasmid (h) - sc-402816-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GRK 4 Double Nickase Plasmid (h2) - sc-402816-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GRK 4 CRISPR Activation Plasmid (h) - sc-402816-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GRK 4 CRISPR Activation Plasmid (h2) - sc-402816-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GRK 4 Lentiviral Activation Particles (h) - sc-402816-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GRK 4 Lentiviral Activation Particles (h2) - sc-402816-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GRK 4 siRNA (h) - sc-35516 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GRK 4 shRNA Plasmid (h) - sc-35516-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GRK 4 shRNA (h) Lentiviral Particles - sc-35516-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GRK4 RNAi - H00002868-R08 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

GRK4 RNAi - H00002868-R06 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

GRK4 RNAi - H00002868-R07 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

GRK4 RNAi - H00002868-R05 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU070881 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK0856 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK0855 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK0854 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN9697 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9697 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

GRK4 siRNA (Human) - CRH1926 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GRK4 - MBS8241277 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GRK 4 CRISPR/Cas9 KO Plasmid (h2) - sc-402816-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GRK 4 HDR Plasmid (h2) - sc-402816-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human
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