| Gene Symbol | GNAI3 |
|---|---|
| Entrez Gene | 2773 |
| Alt Symbol | 87U6, ARCND1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 |
| Other Description | g(i) alpha-3|guanine nucleotide-binding protein G(k) subunit alpha |
| Swissprots | P08754 P17539 Q5TZX1 |
| Accessions | AAA35895 EAW56393 P08754 AF493907 AAM12621 AI684171 AK130069 AK311691 AK312252 BAG35184 AW984247 BC025285 AAH25285 BE886720 BI492787 BP289420 BT019973 AAV38776 BT019974 AAV38777 BU195094 BU622030 CX165017 DQ892862 ABM83788 DQ896111 ABM87110 J03005 AAA52557 J03198 AAA35896 J03238 AAA35939 M27543 AAA52579 NM_006496 NP_006487 |
| Function | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor- regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division. {ECO:0000269|PubMed:17635935}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:17635935}. Cell membrane {ECO:0000269|PubMed:17635935}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17635935}. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody. |
| Top Pathways | Circadian entrainment, Oxytocin signaling pathway, Estrogen signaling pathway, Adrenergic signaling in cardiomyocytes, Glutamatergic synapse |