Gene Symbol | GNAI3 |
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Entrez Gene | 2773 |
Alt Symbol | 87U6, ARCND1 |
Species | Human |
Gene Type | protein-coding |
Description | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 |
Other Description | g(i) alpha-3|guanine nucleotide-binding protein G(k) subunit alpha |
Swissprots | P08754 P17539 Q5TZX1 |
Accessions | AAA35895 EAW56393 P08754 AF493907 AAM12621 AI684171 AK130069 AK311691 AK312252 BAG35184 AW984247 BC025285 AAH25285 BE886720 BI492787 BP289420 BT019973 AAV38776 BT019974 AAV38777 BU195094 BU622030 CX165017 DQ892862 ABM83788 DQ896111 ABM87110 J03005 AAA52557 J03198 AAA35896 J03238 AAA35939 M27543 AAA52579 NM_006496 NP_006487 |
Function | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor- regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division. {ECO:0000269|PubMed:17635935}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:17635935}. Cell membrane {ECO:0000269|PubMed:17635935}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17635935}. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody. |
Top Pathways | Circadian entrainment, Oxytocin signaling pathway, Estrogen signaling pathway, Adrenergic signaling in cardiomyocytes, Glutamatergic synapse |
G α i-3 CRISPR/Cas9 KO Plasmid (h) - sc-400453 from Santa Cruz Biotechnology
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G α i-3 HDR Plasmid (h) - sc-400453-HDR from Santa Cruz Biotechnology
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G α i-3 Double Nickase Plasmid (h) - sc-400453-NIC from Santa Cruz Biotechnology
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G α i-3 Double Nickase Plasmid (h2) - sc-400453-NIC-2 from Santa Cruz Biotechnology
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G α i-3 CRISPR Activation Plasmid (h) - sc-400453-ACT from Santa Cruz Biotechnology
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G α i-3 CRISPR Activation Plasmid (h2) - sc-400453-ACT-2 from Santa Cruz Biotechnology
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G α i-3 Lentiviral Activation Particles (h) - sc-400453-LAC from Santa Cruz Biotechnology
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G α i-3 Lentiviral Activation Particles (h2) - sc-400453-LAC-2 from Santa Cruz Biotechnology
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G α i-3 siRNA (h) - sc-29325 from Santa Cruz Biotechnology
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G α i-3 shRNA Plasmid (h) - sc-29325-SH from Santa Cruz Biotechnology
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G α i-3 shRNA (h) Lentiviral Particles - sc-29325-V from Santa Cruz Biotechnology
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GNAI3 RNAi - H00002773-R01 from Novus Biologicals
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MISSION® esiRNA - EHU052191 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9406 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9406 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11306 from Sigma-Aldrich
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GNAI3 siRNA (Human) - CRH1843 from Cohesion Biosciences
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GNAI3 - MBS8225807 from MyBioSource
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shRNA set against Human GNAI3 (NM_006496.3) - SHH304638 from Creative biogene
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GNAI3 shRNA Plasmid (Human) - CHH1843 from Cohesion Biosciences
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GNAI3 miRNA 3'UTR clone - MiUTR4H-TG03881 from Creative biogene
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