Gene Symbol | AGAP1 |
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Entrez Gene | 116987 |
Alt Symbol | AGAP-1, CENTG2, GGAP1, cnt-g2 |
Species | Human |
Gene Type | protein-coding |
Description | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 |
Other Description | Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 1|GTP-binding and GTPase-activating protein 1|arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1|centaurin, gamma 2 |
Swissprots | Q9NV93 B2RTX7 Q541S5 Q9UPQ3 Q6P9D7 |
Accessions | AAX88852 AAX88857 AAY14697 AAY24137 EAW71078 EAW71079 Q9UPQ3 AB029022 BAA83051 AF413078 AAL04172 AK001722 BAA91862 AK295520 BAG58435 AK300763 BAG62428 AY033765 AAK56506 BC060814 AAH60814 BC140856 AAI40857 BC167153 AAI67153 BC167157 AAI67157 BI868924 BM752978 CA446024 CB961699 DQ570804 DQ584637 KJ534764 AHW56404 XM_005246059 XP_005246116 XM_006712234 XP_006712297 XM_006712235 XP_006712298 XM_006712237 XP_006712300 XM_006712239 XP_006712302 XM_011510547 XP_011508849 XM_011510548 XP_011508850 XM_011510549 XP_011508851 NM_001037131 NP_001032208 NM_001244888 NP_001231817 NM_014914 NP_055729 |
Function | GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system. {ECO:0000269|PubMed:12640130}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:12388557, ECO:0000269|PubMed:12640130}. Note=Associates with the endocytic compartment. |
Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:12388557, ECO:0000269|PubMed:12640130, ECO:0000269|PubMed:15381706, ECO:0000269|PubMed:16079295}. |
Top Pathways | Endocytosis |
AGAP1 CRISPR/Cas9 KO Plasmid (h) - sc-409504 from Santa Cruz Biotechnology
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AGAP1 HDR Plasmid (h) - sc-409504-HDR from Santa Cruz Biotechnology
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AGAP1 Double Nickase Plasmid (h) - sc-409504-NIC from Santa Cruz Biotechnology
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AGAP1 Double Nickase Plasmid (h2) - sc-409504-NIC-2 from Santa Cruz Biotechnology
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AGAP1 CRISPR Activation Plasmid (h) - sc-409504-ACT from Santa Cruz Biotechnology
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AGAP1 CRISPR Activation Plasmid (h2) - sc-409504-ACT-2 from Santa Cruz Biotechnology
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AGAP1 Lentiviral Activation Particles (h) - sc-409504-LAC from Santa Cruz Biotechnology
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AGAP1 Lentiviral Activation Particles (h2) - sc-409504-LAC-2 from Santa Cruz Biotechnology
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AGAP1 siRNA (h) - sc-44443 from Santa Cruz Biotechnology
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AGAP1 shRNA Plasmid (h) - sc-44443-SH from Santa Cruz Biotechnology
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AGAP1 shRNA (h) Lentiviral Particles - sc-44443-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU151651 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2926 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2926 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09247 from Sigma-Aldrich
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AGAP1 siRNA (Human) - CRJ4545 from Cohesion Biosciences
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AGAP1 - MBS8200378 from MyBioSource
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shRNA set against Human AGAP1 (NM_014914.4) - SHH233106 from Creative biogene
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AGAP1 shRNA Plasmid (Human) - CHJ4545 from Cohesion Biosciences
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AGAP1 miRNA 3'UTR clone - MiUTR3H-10132 from Creative biogene
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AGAP1 miRNA 3'UTR clone - MiUTR3H-10133 from Creative biogene
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