| Gene Symbol |
TBC1D2
|
| Entrez Gene |
55357
|
| Alt Symbol |
PARIS-1, PARIS1, TBC1D2A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TBC1 domain family, member 2
|
| Other Description |
TBC1 domain family member 2A|TBC1 domain family, member 2A|armus|prostate antigen recognized and identified by SEREX 1
|
| Swissprots |
Q59EU0 Q9BYX2 Q9NSH4 Q8WYT1 B9A6J7 Q9H6A2 B3KWD1 B4DQ05 Q5TBQ5 Q6IPC7 Q7L1K8
|
| Accessions |
EAW58882 EAW58883 EAW58884 EAW58885 EAW58886 EAW58887 EAW58888 Q9BYX2 AB209721 BAD92958 AB449882 BAH16625 AF318370 AAL55877 AK026105 BAB15361 AK124772 BAG54093 AK131290 BAG54761 AK298575 BAG60767 AL353935 CAB89247 AY026527 AAK07684 BC028918 AAH28918 BC071978 AAH71978 BX091503 DB167423 DQ891305 ABM82231 DQ894490 ABM85416 XM_011518843 XP_011517145 XM_011518844 XP_011517146 XR_929823 XR_929824 NM_001267571 NP_001254500 NM_001267572 NP_001254501 NM_018421 NP_060891 NR_051978
|
| Function |
Acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion. {ECO:0000269|PubMed:20116244}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:20116244}. Cytoplasmic vesicle {ECO:0000269|PubMed:20116244}. Cell junction {ECO:0000269|PubMed:20116244}.
|
| Tissue Specificity |
Expressed in a broad range of tissues, especially in kidney, liver, lung and placenta. Also expressed in keratinocytes and epithelia-containing organs. Isoform 2 is differentially expressed in prostate normal and cancer cells (at protein level). {ECO:0000269|PubMed:11785977, ECO:0000269|PubMed:20116244}.
|
![Western Blot: TBC1D2 Overexpression Lysate (Adult Normal) [NBP2-06798] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TBC1D2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/16420_TBC1D2%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-06798-img0001.jpg)