| Gene Symbol |
DNASE1L2
|
| Entrez Gene |
1775
|
| Alt Symbol |
DNAS1L2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
deoxyribonuclease I-like 2
|
| Other Description |
DNase I homolog protein DHP1|DNase I-like 2|deoxyribonuclease-1-like 2
|
| Swissprots |
E9PBY4 Q6JVM3 Q6JVM2 Q92874
|
| Accessions |
AAQ73760 AAQ73761 EAW85526 EAW85527 EAW85528 EAW85529 Q92874 AK098028 BAG53566 AY298957 AAQ73759 BC035205 AAH35205 BC063710 AAH63710 U62647 AAB63981 XM_011522399 XP_011520701 NM_001301680 NP_001288609 NM_001374 NP_001365
|
| Function |
Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by damaged epidermal cells. {ECO:0000269|PubMed:16902420}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:16902420}. Secreted {ECO:0000305}.
|
| Tissue Specificity |
Preferentially expressed in the skin and up- regulated during keratinocytes differentiation. Highly abundant (at protein level) in the stratum granulosum. {ECO:0000269|PubMed:16902420}.
|
