ERO1LB

Gene Symbol ERO1LB
Entrez Gene 56605
Alt Symbol -
Species Human
Gene Type protein-coding
Description ERO1-like beta (S. cerevisiae)
Other Description ERO1-L-beta|ERO1-like protein beta|endoplasmic oxidoreductin-1-like protein B|endoplasmic reticulum oxidoreductin-1-like protein B|oxidoreductin-1-L-beta
Swissprots B4DF57 Q86YB8 Q9NR62 Q8IZ11 Q5T1H4
Accessions EAW70045 EAW70046 Q86YB8 AF252538 AAF97547 AK001865 AK293941 BAG57318 AK315351 BAG37747 BC032823 AAH32823 BC044573 AAH44573 BG723126 BX648202 CR749523 HQ448024 ADQ32505 NM_019891 NP_063944
Function Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50% of P4HB reoxidation rate), as well as PDIA3, PDIA4, PDIA6 and NXNDC12 (<10%). Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. May be involved in oxidative proinsulin folding in pancreatic cells, hence may play a role in glucose homeostasis. {ECO:0000269|PubMed:11707400, ECO:0000269|PubMed:21091435}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:10818100}; Peripheral membrane protein {ECO:0000269|PubMed:10818100}; Lumenal side {ECO:0000269|PubMed:10818100}. Note=The association with ERP44 may be essential for its retention in the endoplasmic reticulum.
Tissue Specificity Highly expressed in the digestive tract, including the duodenum and lower digestive tract. In the stomach, highly expressed in enzyme-producing chief cells (at protein level). In the pancreas, expressed in islets of Langerhans and, at lower levels, in enzyme-secreting cells (at protein level). Detected at low level in many other tissues. {ECO:0000269|PubMed:10818100, ECO:0000269|PubMed:16012172}.
Top Pathways Protein processing in endoplasmic reticulum

Anti-ERO1LB antibody - ab197290 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-ERO1LB antibody (ab197290) at 1/500 dilution + human fetal testis lysate

Anti-ERO1LB antibody - ab103704 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-ERO1LB antibody (ab103704) at 1/100 dilution + MDA-MB435 cell lysate at 35 µg

Anti-ERO1LB Antibody (aa266-293) IHC-plus™ - LS-B10234 from LifeSpan Bioscience

Prices $395.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-ERO1LB antibody IHC staining of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-ERO1LB Antibody (aa274-304, APC) - LS-C213971 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERO1LB Antibody (aa274-304, FITC) - LS-C213974 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERO1LB Antibody (aa274-304, Biotin) - LS-C213973 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERO1LB Antibody (aa274-304, Azide-free, HRP) - LS-C213975 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERO1LB Antibody (aa274-304, AP) - LS-C213970 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERO1LB Antibody (aa274-304, PE) - LS-C213976 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERO1LB Antibody (aa274-304) - LS-C321185 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERO1LB Antibody - LS-C332714 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of Mouse brain cell line, using ERO1LB antibody.

ERO1LB Antibody - NBP1-83961 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: ERO1LB Antibody [NBP1-83961] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp. Lane 4: Human plasma (IgG/HSA depleted). Lane 5: Human liver tissue

Anti-ERO1LB (281-295) antibody produced in rabbit - SAB1102198 from Sigma-Aldrich

Prices $298.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human ERO1LB was separated on SDS-PAGE, blotted with Anti-ERO1LB (281-295) (<B>Cat. No. SAB1102198</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate. <BR/><B>Lanes</B><BR/>1. Antibody dilution 1:1,000 <BR/>2. Antibody dilution 1:1,000 + ERO1LB immunizing peptide (human, 281-295)

Anti-ERO1LB (111-125) antibody produced in rabbit - SAB1102197 from Sigma-Aldrich

Prices $298.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human ERO1LB was separated on SDS-PAGE, blotted with Anti-ERO1LB (111-125) (<B>Cat. No. SAB1102197</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate. <BR/><B>Lanes</B><BR/>1. Antibody dilution 1:500

Anti-ERO1LB antibody produced in rabbit - HPA028085 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-ERO1LB: <B>Cat. No. HPA028085</B>: Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine cells.

ERO1LB Antibody - C-terminal region (OAAB02635) - OAAB02635 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

ERO1LB-Antibody-C-term - AP5218b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
ERO1LB Antibody (C-term) (Cat. #AP5218b) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).   This demonstrates the ERO1LB antibody detected the ERO1LB protein (arrow).

ERO1LB antibody - GTX53598 from GeneTex

Prices $319.00
Sizes 400 μl
Host Rabbit
Clonality Polyclonal
Anti-ERO1LB antibody used in Flow cytometry/FACS. GTX53598

Anti -ERO1LB (ERO1-like Protein beta, Endoplasmic Oxidoreductin-1-like Protein B) - 210737 from USBiological Life Science

Host Rabbit
Clonality Polyclonal
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