ERO1LB

Gene Symbol	ERO1LB
Entrez Gene	56605
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	ERO1-like beta (S. cerevisiae)
Other Description	ERO1-L-beta|ERO1-like protein beta|endoplasmic oxidoreductin-1-like protein B|endoplasmic reticulum oxidoreductin-1-like protein B|oxidoreductin-1-L-beta
Swissprots	B4DF57 Q86YB8 Q9NR62 Q8IZ11 Q5T1H4
Accessions	EAW70045 EAW70046 Q86YB8 AF252538 AAF97547 AK001865 AK293941 BAG57318 AK315351 BAG37747 BC032823 AAH32823 BC044573 AAH44573 BG723126 BX648202 CR749523 HQ448024 ADQ32505 NM_019891 NP_063944
Function	Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50% of P4HB reoxidation rate), as well as PDIA3, PDIA4, PDIA6 and NXNDC12 (<10%). Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. May be involved in oxidative proinsulin folding in pancreatic cells, hence may play a role in glucose homeostasis. {ECO:0000269|PubMed:11707400, ECO:0000269|PubMed:21091435}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:10818100}; Peripheral membrane protein {ECO:0000269|PubMed:10818100}; Lumenal side {ECO:0000269|PubMed:10818100}. Note=The association with ERP44 may be essential for its retention in the endoplasmic reticulum.
Tissue Specificity	Highly expressed in the digestive tract, including the duodenum and lower digestive tract. In the stomach, highly expressed in enzyme-producing chief cells (at protein level). In the pancreas, expressed in islets of Langerhans and, at lower levels, in enzyme-secreting cells (at protein level). Detected at low level in many other tissues. {ECO:0000269|PubMed:10818100, ECO:0000269|PubMed:16012172}.
Top Pathways	Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ERO1LB full length protein - ab132912 from Abcam Category Protein Source Wheat germ Species Human

Human ERO1LB protein fragment - ab127320 from Abcam Category Protein Source E. coli Species Human

ERO1LB Antibody Blocking Peptide - LS-E7774 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ERO1LB Protein - H00056605-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ERO1LB-Antibody-C-term-Blocking-peptide - BP5218b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ERO1LB - H00056605-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ERO1LB - H00056605-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

ERO1LB fusion protein - ag17920 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

ERO1LB fusion protein - ag1776 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human ERO1-like protein beta(ERO1LB) - CSB-YP774834HU CSB-EP774834HU CSB-BP774834HU CSB-MP774834HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

ERO1LB - TP308445 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

ERO1LB Recombinant Protein Antigen - NBP1-83961PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ERO1LB Peptide, Human - M34GP05062H from Creative Peptides Category Peptide Source Synthetic. Species Human

ERO1-like protein beta (ERO1LB), Recombinant Protein - MBS1479915 from MyBioSource Category Protein Prices $1,210.00, $1,210.00, $1,430.00, $1,430.00, $1,960.00, $1,960.00, $2,425.00, $2,425.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Search more