| Gene Symbol |
ERO1LB
|
| Entrez Gene |
56605
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ERO1-like beta (S. cerevisiae)
|
| Other Description |
ERO1-L-beta|ERO1-like protein beta|endoplasmic oxidoreductin-1-like protein B|endoplasmic reticulum oxidoreductin-1-like protein B|oxidoreductin-1-L-beta
|
| Swissprots |
B4DF57 Q86YB8 Q9NR62 Q8IZ11 Q5T1H4
|
| Accessions |
EAW70045 EAW70046 Q86YB8 AF252538 AAF97547 AK001865 AK293941 BAG57318 AK315351 BAG37747 BC032823 AAH32823 BC044573 AAH44573 BG723126 BX648202 CR749523 HQ448024 ADQ32505 NM_019891 NP_063944
|
| Function |
Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50% of P4HB reoxidation rate), as well as PDIA3, PDIA4, PDIA6 and NXNDC12 (<10%). Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. May be involved in oxidative proinsulin folding in pancreatic cells, hence may play a role in glucose homeostasis. {ECO:0000269|PubMed:11707400, ECO:0000269|PubMed:21091435}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:10818100}; Peripheral membrane protein {ECO:0000269|PubMed:10818100}; Lumenal side {ECO:0000269|PubMed:10818100}. Note=The association with ERP44 may be essential for its retention in the endoplasmic reticulum.
|
| Tissue Specificity |
Highly expressed in the digestive tract, including the duodenum and lower digestive tract. In the stomach, highly expressed in enzyme-producing chief cells (at protein level). In the pancreas, expressed in islets of Langerhans and, at lower levels, in enzyme-secreting cells (at protein level). Detected at low level in many other tissues. {ECO:0000269|PubMed:10818100, ECO:0000269|PubMed:16012172}.
|
| Top Pathways |
Protein processing in endoplasmic reticulum
|