IGF1
| Gene Symbol | IGF1 |
|---|---|
| Entrez Gene | 3479 |
| Alt Symbol | IGF-I, IGF1A, IGFI |
| Species | Human |
| Gene Type | protein-coding |
| Description | insulin-like growth factor 1 (somatomedin C) |
| Other Description | IGF-IA|IGF-IB|MGF|insulin-like growth factor I|insulin-like growth factor IA|insulin-like growth factor IB|mechano growth factor|somatomedin-C |
| Swissprots | Q14620 P01343 B2RWM7 P05019 E9PD02 |
| Accessions | AAA52537 AAA52538 AAA52788 AAA52790 AAB21519 AAO74829 AAV40833 CAA27152 CAA27153 CAA27154 CAA27250 CAY39134 EAW97695 EAW97696 EAW97697 EAW97698 P05019 AB209184 BAD92421 AK312231 BAG35164 BC148266 AAI48267 BC152321 AAI52322 BC160082 AAI60082 CR541861 CAG46659 M11568 AAA52539 M27544 AAA52787 M29644 AAA52543 M37484 AAA52789 U40870 AAA96152 X00173 CAA24998 X56773 CAA40092 X56774 CAA40093 X57025 CAA40342 XR_944534 XR_944535 XR_944536 NM_000618 NP_000609 NM_001111283 NP_001104753 NM_001111284 NP_001104754 NM_001111285 NP_001104755 |
| Function | The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. {ECO:0000269|PubMed:21076856, ECO:0000269|PubMed:24132240}. |
| Subcellular Location | Secreted. |
| Top Pathways | Focal adhesion, Rap1 signaling pathway, Long-term depression, Proteoglycans in cancer, Signaling pathways regulating pluripotency of stem cells |
IGF-I CRISPR/Cas9 KO Plasmid (h) - sc-400271 from Santa Cruz Biotechnology
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IGF-I HDR Plasmid (h) - sc-400271-HDR from Santa Cruz Biotechnology
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IGF-I Double Nickase Plasmid (h) - sc-400271-NIC from Santa Cruz Biotechnology
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IGF-I Double Nickase Plasmid (h2) - sc-400271-NIC-2 from Santa Cruz Biotechnology
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IGF-I CRISPR Activation Plasmid (h) - sc-400271-ACT from Santa Cruz Biotechnology
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IGF-I CRISPR Activation Plasmid (h2) - sc-400271-ACT-2 from Santa Cruz Biotechnology
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IGF-I Lentiviral Activation Particles (h) - sc-400271-LAC from Santa Cruz Biotechnology
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IGF-I Lentiviral Activation Particles (h2) - sc-400271-LAC-2 from Santa Cruz Biotechnology
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IGF-I siRNA (h) - sc-37193 from Santa Cruz Biotechnology
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IGF-I shRNA Plasmid (h) - sc-37193-SH from Santa Cruz Biotechnology
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IGF-I shRNA (h) Lentiviral Particles - sc-37193-V from Santa Cruz Biotechnology
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IGF-I RNAi - H00003479-R04 from Novus Biologicals
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IGF-I RNAi - H00003479-R03 from Novus Biologicals
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MISSION® esiRNA - EHU059801 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1099 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1099 from Sigma-Aldrich
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IGF1 siRNA (Human) - CRH2350 from Cohesion Biosciences
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IGF-I RNAi - H00003479-R01 from Novus Biologicals
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IGF-I RNAi - H00003479-R02 from Novus Biologicals
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IGF1 - MBS8213949 from MyBioSource
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shRNA set against Human IGF1 (NM_000618.3) - SHH317433 from Creative biogene
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shRNA set against Human IGF1(NM_001111283.1) - SHL167686 from Creative biogene
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shRNA set against Human IGF1(NM_000618.3) - SHL167862 from Creative biogene
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IGF1 shRNA Plasmid (Human) - CHH2350 from Cohesion Biosciences
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IGF1 miRNA 3'UTR clone - MiUTR1H-04830 from Creative biogene
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