| Gene Symbol |
STAT1
|
| Entrez Gene |
6772
|
| Alt Symbol |
CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
signal transducer and activator of transcription 1, 91kDa
|
| Other Description |
signal transducer and activator of transcription 1, 91kD|signal transducer and activator of transcription 1-alpha/beta|signal transducer and activator of transcription-1|transcription factor ISGF-3 components p91/p84
|
| Swissprots |
Q68D00 A8K989 Q53S88 Q53XW4 P42224 B2RCA0 Q9UDL5 D2KFR8 D3DPI7
|
| Accessions |
AAF04559 AAR13284 AAW56072 AAY24183 CAD22974 CAM91174 CAM91175 EAX10850 EAX10851 EAX10852 EAX10853 EAX10854 EAX10855 P42224 AI992149 AK096686 AK225853 AK292604 BAF85293 AK315002 BAG37497 BC002704 AAH02704 BC141921 AAI41922 BG699050 BT007241 AAP35905 BU738296 BX400908 CN410740 CR749636 CAH18430 CR998778 DA313984 EB385742 EU831980 ACE87421 EU832073 ACE86735 GU211347 ADA59516 GU211348 ADA59517 M97935 AAB64012 M97936 XM_006712718 XP_006712781 NM_007315 NP_009330 NM_139266 NP_644671
|
| Function |
Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN- stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN- gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral stat
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:15322115}. Nucleus {ECO:0000269|PubMed:15322115}. Note=Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to IFN-gamma and signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4.
|
| Top Pathways |
Prolactin signaling pathway, Tuberculosis, Herpes simplex infection, Osteoclast differentiation, Inflammatory bowel disease (IBD)
|