STAT1

Gene Symbol	STAT1
Entrez Gene	6772
Alt Symbol	CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91
Species	Human
Gene Type	protein-coding
Description	signal transducer and activator of transcription 1, 91kDa
Other Description	signal transducer and activator of transcription 1, 91kD|signal transducer and activator of transcription 1-alpha/beta|signal transducer and activator of transcription-1|transcription factor ISGF-3 components p91/p84
Swissprots	Q68D00 A8K989 Q53S88 Q53XW4 P42224 B2RCA0 Q9UDL5 D2KFR8 D3DPI7
Accessions	AAF04559 AAR13284 AAW56072 AAY24183 CAD22974 CAM91174 CAM91175 EAX10850 EAX10851 EAX10852 EAX10853 EAX10854 EAX10855 P42224 AI992149 AK096686 AK225853 AK292604 BAF85293 AK315002 BAG37497 BC002704 AAH02704 BC141921 AAI41922 BG699050 BT007241 AAP35905 BU738296 BX400908 CN410740 CR749636 CAH18430 CR998778 DA313984 EB385742 EU831980 ACE87421 EU832073 ACE86735 GU211347 ADA59516 GU211348 ADA59517 M97935 AAB64012 M97936 XM_006712718 XP_006712781 NM_007315 NP_009330 NM_139266 NP_644671
Function	Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN- stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN- gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral stat
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:15322115}. Nucleus {ECO:0000269|PubMed:15322115}. Note=Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to IFN-gamma and signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4.
Top Pathways	Prolactin signaling pathway, Tuberculosis, Herpes simplex infection, Osteoclast differentiation, Inflammatory bowel disease (IBD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human STAT1 alpha full length protein - ab140412 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human STAT1 full length protein - ab82610 from Abcam Category Protein Source Baculovirus Species Human

Human STAT1 full length protein - ab159594 from Abcam Category Protein Source Wheat germ Species Human

Human STAT1 full length protein - ab173079 from Abcam Category Protein Source E. coli Species Human

Human STAT1 full length protein - ab43616 from Abcam Category Protein Source E. coli Species Human

Human STAT1 peptide - ab39856 from Abcam Category Peptide Species Human

Human STAT1 protein fragment - ab159595 from Abcam Category Protein Source Wheat germ Species Human

STAT1 peptide - ab2416 from Abcam Category Peptide

STAT1 peptide - ab106209 from Abcam Category Peptide

STAT1 Antibody Blocking Peptide - LS-E13261 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

STAT1 Antibody Blocking Peptide - LS-E13262 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

STAT1 Antibody Blocking Peptide - LS-E7321 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

STAT1 Antibody Blocking Peptide - LS-E11775 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

STAT1 Antibody Blocking Peptide - LS-E11776 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

STAT1 Antibody Blocking Peptide - LS-E31389 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

STAT1 Antibody Blocking Peptide - LS-E14028 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

STAT1 Antibody Blocking Peptide - LS-E29833 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

STAT1 Recombinant Protein - H00006772-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

STAT1 Partial Recombinant Protein - H00006772-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human STAT1 Protein - NBP1-48331 from Novus Biologicals Category Protein Prices $349.00, $969.00 Sizes 50 µg, 250 µg Source E.coli Species Human

STAT1 Peptide - P1421 from Novus Biologicals Category Peptide Species Human

Phospho-STAT1S727-Antibody-Blocking-peptide - BP3256a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

STAT1 Protein (OPPA01173) - OPPA01173 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

Human Signal Transducer and Activator of Transcription 1 protein - orb80870 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E.coli

Human STAT1 R protein - orb163464 from Biorbyt Category Protein Prices $323.00, $485.00, $2,074.00, $2,933.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source E. coli Species Human

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