STAT1

Gene Symbol STAT1
Entrez Gene 6772
Alt Symbol CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91
Species Human
Gene Type protein-coding
Description signal transducer and activator of transcription 1, 91kDa
Other Description signal transducer and activator of transcription 1, 91kD|signal transducer and activator of transcription 1-alpha/beta|signal transducer and activator of transcription-1|transcription factor ISGF-3 components p91/p84
Swissprots Q68D00 A8K989 Q53S88 Q53XW4 P42224 B2RCA0 Q9UDL5 D2KFR8 D3DPI7
Accessions AAF04559 AAR13284 AAW56072 AAY24183 CAD22974 CAM91174 CAM91175 EAX10850 EAX10851 EAX10852 EAX10853 EAX10854 EAX10855 P42224 AI992149 AK096686 AK225853 AK292604 BAF85293 AK315002 BAG37497 BC002704 AAH02704 BC141921 AAI41922 BG699050 BT007241 AAP35905 BU738296 BX400908 CN410740 CR749636 CAH18430 CR998778 DA313984 EB385742 EU831980 ACE87421 EU832073 ACE86735 GU211347 ADA59516 GU211348 ADA59517 M97935 AAB64012 M97936 XM_006712718 XP_006712781 NM_007315 NP_009330 NM_139266 NP_644671
Function Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN- stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN- gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral stat
Subcellular Location Cytoplasm {ECO:0000269|PubMed:15322115}. Nucleus {ECO:0000269|PubMed:15322115}. Note=Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to IFN-gamma and signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4.
Top Pathways Prolactin signaling pathway, Tuberculosis, Herpes simplex infection, Osteoclast differentiation, Inflammatory bowel disease (IBD)

Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Alexa Fluor ® 647 Conjugate) - 8009 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone 58D6
Flow cytometric analysis of Jurkat cells, untreated (blue) or treated with hIFN-α1 #8927 (green), using Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Alexa Fluor ® 647 Conjugate).

Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Alexa Fluor ® 555 Conjugate) - 8183 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone 58D6
Confocal immunofluorescent analysis of HeLa cells, untreated (left) or treated (+) with IFN-α (right), using Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Alexa Fluor ® 555 Conjugate) (red) and β-Tubulin (9F3) Rabbit mAb (Alexa Fluor ® 488 Conjugate) #3623 (green).

Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Biotinylated) - 5375 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 58D6
Western blot analysis of extracts from HeLa cells, untreated (-) or treated (+) with Human Interferon-α1 (hIFN-α1) #8927, using Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Biotinylated).

Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (PE Conjugate) - 8062 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone 58D6
Flow cytometric analysis of Jurkat cells, untreated (blue) or treated with hIFN-α1 #8927 (green), using Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (PE Conjugate).

Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Alexa Fluor ® 488 Conjugate) - 9174 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone 58D6
Flow cytometric analysis of Jurkat cells, untreated (blue) or IFN-α treated (green), using Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Alexa Fluor® 488 Conjugate) (#9174).

Phospho-Stat1 (Ser727) Antibody - 9177 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293 (human), NIH/3T3 (mouse), and C6 (rat) cells, untreated or UV-stimulated, using Phospho-Stat1 (Ser727) Antibody

PhosphoPlus ® Stat1 (Tyr701) Antibody Kit - 9170 from Cell Signaling Technology

Prices $489.00
Sizes 1 kit (10 western blots)
Clonality Polyclonal

Phospho-Stat1 (Ser727) (D3B7) Rabbit mAb - 8826 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D3B7
Western blot analysis of extracts from various cell lines, untreated (-) or UV-treated (2 hr recovery; +), using Phospho-Stat1 (Ser727) (D3B7) Rabbit mAb.

Phospho-Stat1 (Tyr701) (D4A7) Rabbit mAb - 7649 from Cell Signaling Technology

Prices $109.00, $287.00, $678.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Monoclonal
Clone D4A7
Western blot analysis of extracts from HeLa, A20, and PC-12 cells, untreated or treated with Human Interferon-α1 (hIFN-α1) #8927 (10 ng/ml, 30 min), using Phospho-Stat1 (Tyr701) (D4A7) Rabbit mAb (upper) or Stat1 Antibody #9172 (lower).

Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb - 9167 from Cell Signaling Technology

Prices $307.00, $719.00
Sizes 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Monoclonal
Clone 58D6
Western blot analysis of extracts from HeLa cells untreated or treated with interferon-α (IFN-α), using Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (upper) or Stat1 Antibody (#9172) (lower).

Stat1 Antibody - 9172 from Cell Signaling Technology

Prices $99.00, $246.00, $596.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells 48 hours following mock transfection, transfection with non-targeted (control) siRNA or transfection with Stat1 siRNA. Stat1 was detected using Stat1 Antibody #9172, and p42 was detected using p42 MAPK Antibody #9108. The Stat1 Antibody confirms silencing of Stat1 expression, and the p42 MAPK Antibody is used to control for protein loading and siRNA specificity.

Stat1 (9H2) Mouse mAb - 9176 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone 9H2
Western blot analysis of extracts from HeLa cells, untreated or IFN-alpha-treated (100 ng/ml for 5 minutes), using Stat1 (9H2) Mouse mAb.

Stat1 (42H3) Rabbit mAb - 9175 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 42H3
Western blot analysis of extracts from HeLa and COS cells, using Stat1 (42H3) Rabbit mAb (Human Specific).

Phospho-Stat1 (Tyr701) Antibody - 9171 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

Stat1α p91 (H-1) - sc-398524 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Stat1α p91 (H-1): sc-398524. Western blot analysis of Stat1α p91 expression in NIH/3T3 (A) and c4 (B) whole cell lysates.

Stat1 p84/p91 (B-9) - sc-271661 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Stat1 p84/p91 (B-9): sc-271661. Western blot analysis of Stat1 p84/p91 expression in non-transfected: sc-117752 (A) and mouse Stat1 p84/p91 transfected: sc-123815 (B) 293T whole cell lysates.

Stat1 p84/p91 (C-136) - sc-464 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Stat1 p84/p91 (C-136): sc-464. Western blot analysis of Stat1 p84/p91 expression in non-transfected: sc-117752 (A) and mouse Stat1 p84/p91 transfected: sc-123815 (B) 293T whole cell lysates.

Stat1 p84/p91 (E-23) - sc-346 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of Stat1α p91 and Stat1β p84 expression in nuclear extracts of phorbol ester-treated HeLa (A,D), A-431 (B,E) and K-562 (C,F) cells. Antibodies include Stat1α p91 (C-24): sc-345 (AC) and Stat1 p84/p91 (E-23): sc-346 (DF).

Stat1 p84/p91 (M-22) - sc-592 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Stat1 p84/p91 (M-22): sc-592. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic and nuclear staining.

Stat1 p84/p91 (H-95) - sc-98783 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Stat1 p84/p91 (H-95): sc-98783. Western blot analysis of Stat1 p84/p91 expression in HeLa whole cell lysate.

Stat1 p84/p91 (ATO-4E9) - sc-53607 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Hamster
Clonality Monoclonal
Stat1 p84/p91 (ATO-4E9): sc-53607. Western blot analysis of Stat1 p84/p91 expression in HeLa (A), A-431 (B) and K-562 (C) whole cell lysates and HeLa nuclear extract (D).

Stat1α p91 (C-111) - sc-417 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of Stat1 phosphorylation in untreated (A,C) and IFN-γ treated (B,D) SK-MEL-28 cell cultures. Lanes probed respectively, with Stat1α p91 (C-111): sc-417 (A,B) or with p-Stat1 (Tyr 701): sc-7988 (C,D).

Stat1α p91 (C-24) - sc-345 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of Stat1a p91 and Stat1b p84 expression in nuclear extracts of phorbol ester-treated HeLa (A,D), A-431 (B,E) and K-562 (C,F) cells. Antibodies include Stat1a p91 (C-24): sc-345 (AC) and Stat1 p84/p91 (E-23): sc-346 (DF).

Stat1α p91 (M-23) - sc-591 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of Stat1α p91 expression in NIH/3T3 nuclear extracts (A,B). Antibodies tested include Stat1α p91 (M-23): sc-591 (A) and Stat1α p91 (C-111): sc-417 (B).

Stat1 p84/p91 (SM2) - sc-51702 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Stat1 p84/p91 (SM2): sc-51702. Western blot analysis of Stat1 p84/p91 expression in IFN γ-treated SK-MEL-28 whole cell lysate.
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