| Gene Symbol |
PSME2
|
| Entrez Gene |
5721
|
| Alt Symbol |
PA28B, PA28beta, REGbeta
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
|
| Other Description |
11S regulator complex beta subunit|11S regulator complex subunit beta|MCP activator, 31-kD subunit|REG-beta|activator of multicatalytic protease subunit 2|cell migration-inducing protein 22|proteasome activator 28 subunit beta|proteasome activator 28-beta|proteasome activator complex subunit 2|proteasome activator hPA28 subunit beta
|
| Swissprots |
Q15129 Q9UL46
|
| Accessions |
AAF02218 EAW66100 EAW66101 Q9UL46 AK026580 AK225876 AK311569 AY771595 AAX11425 BC004368 AAH04368 BC019885 AAH19885 BC072025 AAH72025 BX161498 CAD61943 CR541657 CAG46458 CR541743 CAG46543 D45248 BAA08205 DQ893404 ABM84330 DQ896722 ABM87721 XM_006720213 XP_006720276 NM_002818 NP_002809
|
| Function |
Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.
|
| Top Pathways |
Proteasome, Antigen processing and presentation
|
![Western Blot: PSME2 Overexpression Lysate (Adult Normal) [NBL1-14908] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PSME2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9426_PSME2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14908-img0002.jpg)