| Gene Symbol | LAT2 |
|---|---|
| Entrez Gene | 7462 |
| Alt Symbol | HSPC046, LAB, NTAL, WBSCR15, WBSCR5, WSCR5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | linker for activation of T cells family, member 2 |
| Other Description | Williams-Beuren syndrome chromosomal region 15 protein|Williams-Beuren syndrome chromosomal region 5 protein|linker for activation of B-cells|linker for activation of T cells, transmembrane adaptor 2|linker for activation of T-cells family member 2|membrane-associated adapter molecule|non-T-cell activation linker |
| Swissprots | D3DXF9 A8K4F1 Q9BXX8 A6NFK6 A8K209 Q9NZY9 Q9GZY6 |
| Accessions | AAF74978 AAS07404 AAS07405 CAC33299 CAE90041 EAW69609 EAW69610 EAW69611 EAW69612 EAW69613 EAW69614 Q9GZY6 AF086239 AF161531 AAF29018 AF252611 AAK37429 AF252612 AAK37430 AF252613 AAK37633 AF252614 AAK37431 AF257135 AAF91352 AI492348 AK002099 BAA92084 AK092904 BAG52627 AK225150 AK290074 BAF82763 AK290916 BAF83605 AY190023 AAO63155 BC001609 AAH01609 BC006080 BC009204 AAH09204 BM468969 EU832618 ACE87709 EU832690 ACE87022 XM_011516558 XP_011514860 NM_014146 NP_054865 NM_032463 NP_115852 NM_032464 NP_115853 |
| Function | Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. {ECO:0000269|PubMed:12486104, ECO:0000269|PubMed:12514734, ECO:0000269|PubMed:15010370}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:12486104, ECO:0000269|PubMed:12514734}; Single-pass type III membrane protein {ECO:0000269|PubMed:12486104, ECO:0000269|PubMed:12514734}. Note=Present in lipid rafts. |
| Tissue Specificity | Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B- cells, NK cells and monocytes. Absent from T-cells (at protein level). {ECO:0000269|PubMed:11124535, ECO:0000269|PubMed:12486104, ECO:0000269|PubMed:12514734, ECO:0000269|PubMed:16160011}. |
NTAL CRISPR/Cas9 KO Plasmid (h) - sc-405729 from Santa Cruz Biotechnology
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NTAL HDR Plasmid (h) - sc-405729-HDR from Santa Cruz Biotechnology
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NTAL Double Nickase Plasmid (h) - sc-405729-NIC from Santa Cruz Biotechnology
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NTAL Double Nickase Plasmid (h2) - sc-405729-NIC-2 from Santa Cruz Biotechnology
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NTAL CRISPR Activation Plasmid (h) - sc-405729-ACT from Santa Cruz Biotechnology
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NTAL CRISPR Activation Plasmid (h2) - sc-405729-ACT-2 from Santa Cruz Biotechnology
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NTAL Lentiviral Activation Particles (h) - sc-405729-LAC from Santa Cruz Biotechnology
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NTAL Lentiviral Activation Particles (h2) - sc-405729-LAC-2 from Santa Cruz Biotechnology
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NTAL siRNA (h) - sc-62703 from Santa Cruz Biotechnology
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NTAL shRNA Plasmid (h) - sc-62703-SH from Santa Cruz Biotechnology
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NTAL shRNA (h) Lentiviral Particles - sc-62703-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU073591 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11567 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11567 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07444 from Sigma-Aldrich
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LAT2 siRNA (Human) - CRH5104 from Cohesion Biosciences
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shRNA set against Human LAT2 (NM_014146.3) - SHH328667 from Creative biogene
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shRNA set against Human LAT2(NM_032463.2) - SHH143147 from Creative biogene
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shRNA set against Human LAT2(NM_014146.3) - SHH143201 from Creative biogene
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shRNA set against Human LAT2(NM_032464.2) - SHH143219 from Creative biogene
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Human LAT2 siRNA - orb265606 from Biorbyt
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LAT2 shRNA Plasmid (Human) - CHH5104 from Cohesion Biosciences
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LAT2 miRNA 3'UTR clone - MiUTR1H-05587 from Creative biogene
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LAT2 miRNA 3'UTR clone - MiUTR3H-07908 from Creative biogene
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LAT2 miRNA 3'UTR clone - MiUTR3H-07909 from Creative biogene
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