LAT2

Gene Symbol LAT2
Entrez Gene 7462
Alt Symbol HSPC046, LAB, NTAL, WBSCR15, WBSCR5, WSCR5
Species Human
Gene Type protein-coding
Description linker for activation of T cells family, member 2
Other Description Williams-Beuren syndrome chromosomal region 15 protein|Williams-Beuren syndrome chromosomal region 5 protein|linker for activation of B-cells|linker for activation of T cells, transmembrane adaptor 2|linker for activation of T-cells family member 2|membrane-associated adapter molecule|non-T-cell activation linker
Swissprots D3DXF9 A8K4F1 Q9BXX8 A6NFK6 A8K209 Q9NZY9 Q9GZY6
Accessions AAF74978 AAS07404 AAS07405 CAC33299 CAE90041 EAW69609 EAW69610 EAW69611 EAW69612 EAW69613 EAW69614 Q9GZY6 AF086239 AF161531 AAF29018 AF252611 AAK37429 AF252612 AAK37430 AF252613 AAK37633 AF252614 AAK37431 AF257135 AAF91352 AI492348 AK002099 BAA92084 AK092904 BAG52627 AK225150 AK290074 BAF82763 AK290916 BAF83605 AY190023 AAO63155 BC001609 AAH01609 BC006080 BC009204 AAH09204 BM468969 EU832618 ACE87709 EU832690 ACE87022 XM_011516558 XP_011514860 NM_014146 NP_054865 NM_032463 NP_115852 NM_032464 NP_115853
Function Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. {ECO:0000269|PubMed:12486104, ECO:0000269|PubMed:12514734, ECO:0000269|PubMed:15010370}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:12486104, ECO:0000269|PubMed:12514734}; Single-pass type III membrane protein {ECO:0000269|PubMed:12486104, ECO:0000269|PubMed:12514734}. Note=Present in lipid rafts.
Tissue Specificity Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B- cells, NK cells and monocytes. Absent from T-cells (at protein level). {ECO:0000269|PubMed:11124535, ECO:0000269|PubMed:12486104, ECO:0000269|PubMed:12514734, ECO:0000269|PubMed:16160011}.

NTAL/LAB (D7I2B) Rabbit mAb - 11986 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D7I2B
Western blot analysis of extracts from RL-7, SEM, and Jurkat cells using NTAL/LAB (D7I2B) Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower).

NTAL/LAB Antibody - 9533 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of total cell lysates from SR and SEM cells, using NTAL/LAB Antibody.

NTAL (6D620) - sc-71729 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
NTAL (6D620): sc-71729. Western blot analysis of NTAL expression in THP-1 (A), U-937 (B) and Raji (C) whole cell lysates.

NTAL (D-7) - sc-271787 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NTAL (D-7): sc-271787. Western blot analysis of NTAL expression in THP-1 (A) and U-937 (B) whole cell lysates.

NTAL (F-9) - sc-398825 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NTAL (F-9): sc-398825. Western blot analysis of NTAL expression in U-937 (A), THP-1 (B), AML-193 (C), Raji (D) and HL-60 (E) whole cell lysates.

NTAL (NAP-07) - sc-51686 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
NTAL (NAP-07): sc-51686. Western blot analysis of NTAL expression in THP-1 (A), U-937 (B) and Raji (C) whole cell lysates.

NTAL (H-217) - sc-67316 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
NTAL (H-217): sc-67316. Western blot analysis of NTAL expression in THP-1 (A) and AML-193 (B) whole cell lysates.

NTAL (S-17) - sc-66797 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NTAL (S-17): sc-66797. Western blot analysis of NTAL expression in U-937 (A) and HL-60 (B) whole cell lysates.

NTAL (W-18) - sc-66799 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NTAL (W-18): sc-66799. Western blot analysis of NTAL expression in THP-1 (A), U-937 (B) and HL-60 (C) whole cell lysates.

Anti-NTAL antibody - ab197664 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue labeling NTAL with ab197664 at 1/15 dilution.

Anti-NTAL antibody - ab36451 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-NTAL antibody (ab36451) at 1 µg/mlLane 1 : NTAL-transfected HEK-293 FT cellsLane 2 : Negative control: Jurkat human leukemia T-cell lineSecondaryLane 2 : goat anti-rabbit antibodyPerformed under non-reducing conditions.Observed band size : 30 kDa (why is the actual band size different from the predicted?)Additional bands at : 58 kDa (possible non-specific binding),65 kDa (possible non-specific binding),70 kDa (possible non-specific binding).

Anti-NTAL antibody - ab123787 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-NTAL antibody (ab123787) at 1/100 dilution + HeLa cell line lysate at 35 µg

Anti-NTAL antibody - ab175448 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-NTAL antibody (ab175448) at 0.01 µg/ml + Human peripheral lymphocytes lysate at 35 µg

Anti-NTAL antibody [NAP-03] - ab1901 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone NAP-03

Anti-NTAL antibody [NAP-07] - ab3992 from Abcam

Prices $380.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone NAP-07
Subcellular localization of NTAL by confocal microscopy in the myeloid cell line THP-1. THP-1 cells were permeabilized and immunostained using antibody NAP-07 (green). Nuclei are vizualized by propidium iodide (red).

Anti-NTAL antibody [NAP-07] (Phycoerythrin) - ab27574 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone NAP-07

Anti-NTAL antibody - C-terminal - ab155334 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-NTAL antibody - C-terminal (ab155334) at 1/500 dilution + Raji whole cell lysate at 30 µg

Anti-LAT2 / NTAL Antibody (aa91-244) - LS-C16986 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-LAT2 / NTAL Antibody (aa91-244) - LS-C16988 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-LAT2 / NTAL Antibody (aa91-244) - LS-C16992 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-LAT2 / NTAL Antibody (aa91-243, clone NAP-07) - LS-C46032 from LifeSpan Bioscience

Prices $290.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone NAP-07

Anti-LAT2 / NTAL Antibody (aa124-203) - LS-C46151 from LifeSpan Bioscience

Prices $290.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-LAT2 / NTAL Antibody (aa30-203) - LS-C46152 from LifeSpan Bioscience

Prices $290.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-LAT2 / NTAL Antibody (aa91-243, clone NAP-07, PE) - LS-C46507 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone NAP-07

Anti-LAT2 / NTAL Antibody (aa196-212) - LS-C73757 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
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