Gene Symbol | CACTIN |
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Entrez Gene | 58509 |
Alt Symbol | C19orf29, NY-REN-24, fSAPc |
Species | Human |
Gene Type | protein-coding |
Description | cactin, spliceosome C complex subunit |
Other Description | NY REN 24 antigen|cactin|functional spliceosome-associated protein c|renal carcinoma antigen NY-REN-24 |
Swissprots | Q9BTA6 A6NNA9 Q9Y5A4 A9UL12 Q7LE08 O75229 Q8WUQ7 |
Accessions | AAC24305 AAC32903 Q8WUQ7 AF052087 AF155102 AAD42868 AK299963 BAG61789 AW027691 AY917150 AAX84551 BC004262 AAH04262 BC019848 AAH19848 BC156484 AAI56485 BC172549 AAI72549 BF196424 CF272634 CN305928 CO248922 XM_011528160 XP_011526462 XM_011528161 XP_011526463 NM_001080543 NP_001074012 NM_021231 NP_067054 |
Function | Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon- regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during early embryonic development. Probably involved in pre-mRNA splicing. {ECO:0000269|PubMed:20829348}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:20829348}. Note=Nuclear localization with a speckled expression pattern in some cells. Colocalizes with NFKBIL1 in the nucleus. |
Cactin CRISPR/Cas9 KO Plasmid (h) - sc-410082 from Santa Cruz Biotechnology
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Cactin HDR Plasmid (h) - sc-410082-HDR from Santa Cruz Biotechnology
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Cactin Double Nickase Plasmid (h) - sc-410082-NIC from Santa Cruz Biotechnology
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Cactin Double Nickase Plasmid (h2) - sc-410082-NIC-2 from Santa Cruz Biotechnology
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Cactin CRISPR Activation Plasmid (h) - sc-410082-ACT from Santa Cruz Biotechnology
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Cactin CRISPR Activation Plasmid (h2) - sc-410082-ACT-2 from Santa Cruz Biotechnology
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Cactin Lentiviral Activation Particles (h) - sc-410082-LAC from Santa Cruz Biotechnology
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Cactin Lentiviral Activation Particles (h2) - sc-410082-LAC-2 from Santa Cruz Biotechnology
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Cactin siRNA (h) - sc-97608 from Santa Cruz Biotechnology
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Cactin shRNA Plasmid (h) - sc-97608-SH from Santa Cruz Biotechnology
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Cactin shRNA (h) Lentiviral Particles - sc-97608-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU134971 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4529 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4529 from Sigma-Aldrich
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CACTIN siRNA (Human) - CRJ1736 from Cohesion Biosciences
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CACTIN - MBS8202887 from MyBioSource
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shRNA set against Human C19orf29(NM_001080543.1) - SHG118175 from Creative biogene
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Human CACTIN siRNA - orb272237 from Biorbyt
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CACTIN shRNA Plasmid (Human) - CHJ1736 from Cohesion Biosciences
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CACTIN miRNA 3'UTR clone - MiUTR1H-01199 from Creative biogene
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CACTIN miRNA 3'UTR clone - MiUTR3H-14008 from Creative biogene
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